The candidate has a background in clinical ophthalmology and ocular epidemiology, and proposes to extend his work and prevention of eye disease into the field of cataract prevention. This application outlines a three-phase training program in cataract-related clinical trials. In the first phase, class classroom training in the theory of clinical trials will be undertaken at the Center for Clinical Trials of the Johns Hopkins School of Public Health under Dr. Curtis Meinert. Courses in Biostatistics and Epidemiology will provide a theoretical framework for the remainder of the training. The second phase will involve practical training in clinical trials under the auspices of the Age-Related Eye Disease Study. (AREDS). AREDS is a randomized, controlled clinical trial designed to explore in prospective fashion the impact of anti-oxidants and other factors on the progression of age-related cataract. The candidate will be supervised by the Study Chairman, Dr. Frederick Ferris, in a program that will include participation in monthly meetings of the AREDS Study Operations Committee and annual meetings of the Data Monitoring Committee and AREDS Technical Group in Bethesda, participation in Quality Control Site Visits and other activities of the Coordinating Center, and analysis of study data. In the final phase of training, the candidate will design and execute a clinical trial, a follow-up on the Linxian Cataract Trials in China. These were the first randomized, controlled trials to demonstrate that supplementation with anti-oxidants could retard progression of cataract. The proposed study will take advantage of continued examination of this cohort, now aged 55 years and above, by the National Cancer Center Institute for cancer-related events, to obtain unique information on the long-term effects of anti-oxidant treatment on lens opacity over 15 years. This study will exploit the candidate's fluency in written and spoken Chinese. Dr. Sheila West will provide overall direction through the three phases of training.

Agency
National Institute of Health (NIH)
Institute
National Eye Institute (NEI)
Type
Mentored Patient-Oriented Research Career Development Award (K23)
Project #
5K23EY000388-05
Application #
6654923
Study Section
Special Emphasis Panel (ZEY1-VSN (01))
Program Officer
Kurinij, Natalie
Project Start
1999-09-01
Project End
2006-08-31
Budget Start
2003-09-01
Budget End
2006-08-31
Support Year
5
Fiscal Year
2003
Total Cost
$188,110
Indirect Cost
Name
Johns Hopkins University
Department
Ophthalmology
Type
Schools of Medicine
DUNS #
001910777
City
Baltimore
State
MD
Country
United States
Zip Code
21218
Wojciechowski, Robert; Congdon, Nathan; Bowie, Heidi et al. (2005) Heritability of refractive error and familial aggregation of myopia in an elderly American population. Invest Ophthalmol Vis Sci 46:1588-92
Congdon, Nathan; Broman, Karl W; Lai, Hong et al. (2005) Cortical, but not posterior subcapsular, cataract shows significant familial aggregation in an older population after adjustment for possible shared environmental factors. Ophthalmology 112:73-7
Nusz, Kevin J; Congdon, Nathan G; Ho, Tang et al. (2005) Rapid, objective detection of cataract-induced blur using a bull's eye photodetector. J Cataract Refract Surg 31:763-70
Wojciechowski, Robert; Congdon, Nathan; Bowie, Heidi et al. (2005) Familial aggregation of hyperopia in an elderly population of siblings in Salisbury, Maryland. Ophthalmology 112:78-83
Chang, Margaret A; Congdon, Nathan G; Bykhovskaya, Irina et al. (2005) The association between myopia and various subtypes of lens opacity: SEE (Salisbury Eye Evaluation) project. Ophthalmology 112:1395-401
Chang, Ta C; Congdon, Nathan G; Wojciechowski, Robert et al. (2005) Determinants and heritability of intraocular pressure and cup-to-disc ratio in a defined older population. Ophthalmology 112:1186-91
Lewis, A; Congdon, N; Munoz, B et al. (2004) Cataract surgery and subtype in a defined, older population: the SEECAT Project. Br J Ophthalmol 88:1512-7
Congdon, Nathan; Broman, Karl W; Lai, Hong et al. (2004) Nuclear cataract shows significant familial aggregation in an older population after adjustment for possible shared environmental factors. Invest Ophthalmol Vis Sci 45:2182-6
Wojciechowski, Robert; Congdon, Nathan; Anninger, William et al. (2003) Age, gender, biometry, refractive error, and the anterior chamber angle among Alaskan Eskimos. Ophthalmology 110:365-75
Bowie, Heidi; Congdon, Nathan G; Lai, Hong et al. (2003) Validity of a personal and family history of cataract and cataract surgery in genetic studies. Invest Ophthalmol Vis Sci 44:2905-8

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