(Candidate's Abstract) Hypoxia is thought to play a role in the pathogenesis of several ocular diseases. It is Clear that hypoxia is the driving force behind the development of retinal neovascularization (NV) in patients with ischemic retinopathies, including diabetic retinopathy and central and branch retinal vein occlusions. Macular edema is another major cause of decreased vision in ischemic retinopathies and it is suspected, but not yet proven that hypoxia plays a critical role. Likewise, it is suspected, but not yet proven, that hypoxia contributes to the development of choroidal neovascularization (CNV) in patients with age-related macular degeneration (AMD). Supplemental inspired oxygen provides a means to enhance oxygenation in the retina and choroid. We propose to use supplemental inspired oxygen to test several hypotheses related to the role of hypoxia in ocular NV and macular edema. The following experimental questions will be addressed. (1) Does supplemental inspired oxygen cause regression or slow progression of retinal NV that is not high risk in patients with diabetic retinopathy? (2) Does supplemental oxygen cause improvement in macular edema in patients with ischemic retinopathy? (3) Does supplemental oxygen cause stabilization or improvement in AMD patients with predominantly occult subfoveal CNV? (4) Does supplemental oxygen decrease recurrent CNV in AMD patients with predominantly classic CNV treated with photodynamic therapy? The answers to these questions will provide important insights into the pathogenesis of retinal diseases that could lead to the development of new treatments.

National Institute of Health (NIH)
National Eye Institute (NEI)
Mentored Patient-Oriented Research Career Development Award (K23)
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Special Emphasis Panel (ZEY1-VSN (02))
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Everett, Donald F
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Johns Hopkins University
Internal Medicine/Medicine
Schools of Medicine
United States
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Do, Diana V; Nguyen, Quan D; Khwaja, Afsheen A et al. (2013) Ranibizumab for edema of the macula in diabetes study: 3-year outcomes and the need for prolonged frequent treatment. JAMA Ophthalmol 131:139-45
Nguyen, Quan Dong; Shah, Syed Mahmood; Browning, David J et al. (2009) A phase I study of intravitreal vascular endothelial growth factor trap-eye in patients with neovascular age-related macular degeneration. Ophthalmology 116:2141-8.e1
Nguyen, Quan Dong; Shah, Syed Mahmood; Hafiz, Gulnar et al. (2008) Intravenous bevacizumab causes regression of choroidal neovascularization secondary to diseases other than age-related macular degeneration. Am J Ophthalmol 145:257-266
Tatlipinar, Sinan; Shah, Syed Mahmood; Campochiaro, Peter A et al. (2007) Intraobserver repeatability of automated versus adjusted optical coherence tomography measurements in patients with neovascular age-related macular degeneration. Ophthalmologica 221:227-32
Gerstenblith, Adam T; Thorne, Jennifer E; Sobrin, Lucia et al. (2007) Punctate inner choroidopathy: a survey analysis of 77 persons. Ophthalmology 114:1201-4
Nguyen, Quan Dong; Shah, Syed Mahmood; Hafiz, Gulnar et al. (2006) A phase I trial of an IV-administered vascular endothelial growth factor trap for treatment in patients with choroidal neovascularization due to age-related macular degeneration. Ophthalmology 113:1522.e1-1522.e14
Nguyen, Quan Dong; Tatlipinar, Sinan; Shah, Syed Mahmood et al. (2006) Vascular endothelial growth factor is a critical stimulus for diabetic macular edema. Am J Ophthalmol 142:961-9
Do, Diana V; Nguyen, Quan Dong; Bressler, Neil M et al. (2006) Hemoglobin A1c awareness among patients receiving eye care at a tertiary ophthalmic center. Am J Ophthalmol 141:951-3
Do, Diana V; Shah, Syed Mahmood; Sung, Jennifer U et al. (2005) Persistent diabetic macular edema is associated with elevated hemoglobin A1c. Am J Ophthalmol 139:620-3
Nguyen, Quan Dong; Shah, Syed Mahmood; Van Anden, Elizabeth et al. (2004) Supplemental oxygen improves diabetic macular edema: a pilot study. Invest Ophthalmol Vis Sci 45:617-24

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