Dr. Elizabeth Bradley's long-term career goal is to study Graves' opthalmopathy as an independent clinical investigator. This application proposes a two-phased career development program that will provide her with many of the tools necessary for future success. In the first two years of the award period, Dr. Bradley will complete course work through the Johns Hopkins School of Public Health's Graduate Train Program in Clinical Investigation. Johns Hopkins ophthalmic epidemiologic Dr. Sheila West will serve as primary mentor throughout the award period. Dr. Bradley will spend the final three years of the award at the Mayo Clinic, completing a study on the impact on Graves' opthalmopathy on health-related quality of life under the guidance of Mayo-based co-mentor Dr. Rebecca Bahn. Johns Hopkins offers Dr. Bradley a mentor with expertise in ophthalmic clinical investigation and the many resources of both its School of Public Health and the School of Medicine's Wilmer Eye Institute. The Mayo Clinic offers a mentor actively engaged in clinical investigation in Graves' opthalmopathy practice, and the resources of an established, NIH-funded quality of life research program. Graves'' opthalmopathy is an infiltrative orbital disease associated with autoimmune thyroid disease. Although medical and surgical interventions have been reported to improve some of the manifestations of the disease, the associated side effects of current treatments for Graves' opthalmopathy often temper their benefits. Additionally, objective indices by which to measure many of the disease manifestations are lacking. These objective measures that do exist fail to provide a comprehensive assessment of the impact of the disease and its treatment on patient health-related quality of life. Dr. Bradley plans to develop a valid, reliable Graves' opthalmopathy-specific HRQL instrument and to obtain baseline epidemiologic data on the performance of the instrument in a population of Graves' opthalmopathy patients. These efforts will serve as important preparatory steps toward Dr. Bradley's long-term goal of studying treatments of Graves' opthalmopathy through medical and surgical clinical trials.

National Institute of Health (NIH)
National Eye Institute (NEI)
Mentored Patient-Oriented Research Career Development Award (K23)
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Special Emphasis Panel (ZEY1-VSN (02))
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Redford, Maryann
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Mayo Clinic, Rochester
United States
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Hatt, Sarah R; Leske, David A; Yamada, Tomohiko et al. (2010) Development and initial validation of quality-of-life questionnaires for intermittent exotropia. Ophthalmology 117:163-168.e1
Hatt, Sarah R; Leske, David A; Bradley, Elizabeth A et al. (2009) Comparison of quality-of-life instruments in adults with strabismus. Am J Ophthalmol 148:558-62
Hatt, Sarah R; Leske, David A; Bradley, Elizabeth A et al. (2009) Development of a quality-of-life questionnaire for adults with strabismus. Ophthalmology 116:139-144.e5
Hatt, Sarah R; Leske, David A; Adams, Wendy E et al. (2008) Quality of life in intermittent exotropia: child and parent concerns. Arch Ophthalmol 126:1525-9
Bradley, Elizabeth A; Gower, Emily W; Bradley, David J et al. (2008) Orbital radiation for graves ophthalmopathy: a report by the American Academy of Ophthalmology. Ophthalmology 115:398-409
Hatt, Sarah R; Leske, David A; Kirgis, Penny A et al. (2007) The effects of strabismus on quality of life in adults. Am J Ophthalmol 144:643-7
Bradley, Elizabeth A; Sloan, Jeff A; Novotny, Paul J et al. (2006) Evaluation of the National Eye Institute visual function questionnaire in Graves' ophthalmopathy. Ophthalmology 113:1450-4
Bradley, Elizabeth A; Bradley, David; Bartley, George B (2006) Evaluating health-related quality of life in ophthalmic disease: practical considerations. Arch Ophthalmol 124:121-2
Edwards, Douglas T; Bartley, George B; Hodge, David O et al. (2004) Eyelid position measurement in Graves' ophthalmopathy: reliability of a photographic technique and comparison with a clinical technique. Ophthalmology 111:1029-34