The principal investigator (PI) is currently funded by a K12 Mentored Clinical Scientist Development Program Award through the Duke University Eye Center. The proposed K23 Career Development Award will provide continued mentored training to assist the PI to become an independent clinician-scientist by the end of the award period. The PI has identified a strong and diverse group of mentors in the field of retinopathy of prematurity (ROP), biomedical engineering, and telemedicine to ensure that the objectives of her research and career development program will be achieved. The PI will also continue to receive didactic training in clinical research. The PI's long-term career goal is to become an independent clinician-scientist focused on adapting innovative strategies to improve access to care and outcomes in underserved communities. Her clinical training and previous work in public health have prepared her to take on the challenges proposed in this career development plan and research proposal. Environment: Duke University and the Duke University Eye Center are superb environments that are well situated to support and nurture the next generation of clinician-scientists. They have the resources, facilities, faculty, and track record of training an supporting successful clinician-scientists. Research Summary: ROP is the leading preventable and treatable cause of blindness in children in the United States.1 While appropriate screening and treatment could reduce the burden of childhood blindness from ROP, an important barrier to effective ROP screening is the shortage of ophthalmologists skilled in ROP screening.2 Thus, alternative methods to screen for ROP are needed. The focus of this proposal is to evaluate a new, FDA-approved, portable, non-contact digital fundus camera, Pictor, for ROP screening. To evaluate the feasibility of using Pictor as an ROP screening tool, we will evaluate the following specific aims: (1) the feasibility of having trained non-ophthalmologist health care workers (HCWs) obtain high-quality Pictor images of the retina of prematurely-born infants at risk for ROP and (2) the accuracy and reliability of grading these Pictor images for """"""""clinically-significant posterior pole disease"""""""" compared to the reference standard of indirect ophthalmoscopy. Non-ophthalmologist HCWs will be trained to acquire images on prematurely-born infants using the Pictor camera during routine weekly ROP rounds in the neonatal intensive care unit. We will evaluate HCW's ability to obtain high-quality images and explore the accuracy of grading these images for """"""""clinically-significant posterior pole disease"""""""" compared to the clinical exam findings obtained on the same day using indirect ophthalmoscopy by a skilled ophthalmologist. The results of this study will offer alternative screening methods for ROP and increase our scope of imaging techniques for use in telemedicine. Our long-term objective is to increase access for ROP screening to those in rural or remote areas to decrease the burden of blindness due to untreated ROP.
This project will evaluate the feasibility of using a new portable, non-contact imaging device for retinopathy of prematurity (ROP) screening. The knowledge gained from this research could change our current screening system for ROP by offering alternative screening methods, decreasing the burden of screening on the limited supply of ophthalmologists skilled in ROP screening, empowering other healthcare professionals to help screen for ROP, and enabling us to increase access for screening to those in rural or remote areas to decrease the burden of blindness due to untreated ROP.
|Huh, Grace J; Simon, Judith; Grace Prakalapakorn, S (2018) Causes of childhood blindness in Ghana: results from a blind school survey in Upper West Region, Ghana, and review of the literature. Int Ophthalmol 38:1415-1423|
|Nasrazadani, David A; Wallace, David K; Freedman, Sharon F et al. (2018) Development of a scale for grading pre-plus and plus disease using retinal images: A pilot study. J AAPOS 22:316-319|
|Prakalapakorn, S Grace; Freedman, Sharon F; Hutchinson, Amy K et al. (2018) Evaluating a Portable, Noncontact Fundus Camera for Retinopathy of Prematurity Screening by Nonophthalmologist Health Care Workers. Ophthalmol Retina 2:864-871|
|Prakalapakorn, Sasapin G; Vickers, Laura A; Estrada, Rolando et al. (2017) Using an Image Fusion Methodology to Improve Efficiency and Traceability of Posterior Pole Vessel Analysis by ROPtool. Open Ophthalmol J 11:143-151|
|Prakalapakorn, S Grace; Meaney-Delman, Dana; Honein, Margaret A et al. (2017) The eyes as a window to improved understanding of the prenatal effects of Zika virus infection. J AAPOS 21:259-261|
|Zhang, Wenlan; Nicholas, Peter; Schuman, Stefanie Gail et al. (2017) Screening for Diabetic Retinopathy Using a Portable, Noncontact, Nonmydriatic Handheld Retinal Camera. J Diabetes Sci Technol 11:128-134|
|Prakalapakorn, S Grace; Wallace, David K; Freedman, Sharon F (2017) Posterior Pole Vascular Changes Before Treatment of Retinopathy of Prematurity. JAMA Ophthalmol 135:1430-1433|
|Raufi, Nikolas N; Wallace, David K; Freedman, Sharon F et al. (2017) Computer-assisted quantification of pre-plus and plus disease in images obtained using Pictor versus video indirect ophthalmoscopy: a pilot study. J AAPOS 21:322-325|
|Raufi, Nikolas N; Morris, Caleb K; Freedman, Sharon F et al. (2016) Facilitated Versus Self-guided Training of Non-ophthalmologists for Grading Pre-plus and Plus Disease Using Fundus Images for Retinopathy of Prematurity Screening. J Pediatr Ophthalmol Strabismus 53:179-85|
|Vickers, Laura A; Freedman, Sharon F; Wallace, David K et al. (2015) ROPtool analysis of images acquired using a noncontact handheld fundus camera (Pictor)--a pilot study. J AAPOS 19:570-2|
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