description): The candidate and his group have developed an ultrasound measure of diaphragm function in an animal model. This new metric has been applied to mechanically ventilated pediatric patients and can discriminate between children with clinically normal and abnormal diaphragm function. The investigators propose to further develop, validate, and apply these ultrasound measures in children with respiratory failure. Once these noninvasive ultrasound measures are fully developed, new medications and/or ventilatory strategies may be trialed in order to improve diaphragm function and reverse the respiratory failure found in these children. The investigators anticipate that these ultrasound measures will influence and alter the management of respiratory failure in critical care medicine in the same way echocardiography has revolutionized the assessment of myocardial function in cardiology. The study aims to: 1) quantify diaphragm function in normal children and those with respiratory failure using our present ultrasound techniques; 2) develop additional ultrasound metrics; 3) validate these ultrasound measures with standard pulmonary function testing and clinical outcomes; and 4) evaluate the efficacy of new medications and/or ventilatory strategies aimed at reversing respiratory failure in children.

Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Mentored Patient-Oriented Research Career Development Award (K23)
Project #
1K23HD040679-01
Application #
6335787
Study Section
Pediatrics Subcommittee (CHHD)
Program Officer
Grave, Gilman D
Project Start
2000-09-01
Project End
2005-08-31
Budget Start
2000-09-01
Budget End
2001-08-31
Support Year
1
Fiscal Year
2000
Total Cost
$151,259
Indirect Cost
Name
University of North Carolina Chapel Hill
Department
Pediatrics
Type
Schools of Medicine
DUNS #
078861598
City
Chapel Hill
State
NC
Country
United States
Zip Code
27599