This Mentored Patient-Oriented Research career Development Award proposal contains didactic coursework, mentored instruction and a clinical research project designed to apply the principles learned. My clinical research interest is in the pathophysiology of endometriosis. The proposed clinical training and research studies in this application are designed to increase my skills in study design and biostatistics, with the ultimate goal of developing into an independent career clinical investigator. Curriculum of the K30 Training Grant in Clinical Research at the University of Michigan is included in the coursework. The goal of the research proposal is to study the effect of a new immunomodulator drug, rosiglitazone, on peritoneal fluid immune factors in women with endometriosis. This same drug will be compared to oral contraceptives as an alternate means of endometriosis-related pain control. Concurrently, laboratory experiments will explore fetal DMA microchimerism as a cause for the chronic immune response seen with endometriosis offering a novel pathophysiological basis for the development of the disease. Dr. Daniel Remick, who has a substantial background in cytokine research, will help guide the laboratory portion of the study. Dr. Robert Taylor, with international expertise on endometriosis, and Dr. Daniel Clauw, Director of the Center for Advancement of Clinical Research, will serve as my mentors on the clinical trials segment. A biostatistician will provide guidance for the design and interpretation of the proposed studies. This project will allow me to move in a translational direction from my basic science research in endometriosis towards clinical trials. Ultimately, the study will lead to a program that will substantially improve the outcome for women with endometriosis.

Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Mentored Patient-Oriented Research Career Development Award (K23)
Project #
5K23HD043952-02
Application #
7059933
Study Section
Pediatrics Subcommittee (CHHD)
Program Officer
Parrott, Estella C
Project Start
2005-05-01
Project End
2010-04-30
Budget Start
2006-05-01
Budget End
2007-04-30
Support Year
2
Fiscal Year
2006
Total Cost
$148,324
Indirect Cost
Name
University of Michigan Ann Arbor
Department
Obstetrics & Gynecology
Type
Schools of Medicine
DUNS #
073133571
City
Ann Arbor
State
MI
Country
United States
Zip Code
48109
Fassbender, Amelie; Debiec-Rychter, Maria; Van Bree, Rieta et al. (2015) Lack of Evidence That Male Fetal Microchimerism is Present in Endometriosis. Reprod Sci 22:1115-21
Lebovic, Dan I; Kavoussi, Shahryar K; Lee, JeHoon et al. (2013) PPAR? activation inhibits growth and survival of human endometriotic cells by suppressing estrogen biosynthesis and PGE2 signaling. Endocrinology 154:4803-13
Herington, Jennifer L; Crispens, Marta A; Carvalho-Macedo, Alessandra C et al. (2011) Development and prevention of postsurgical adhesions in a chimeric mouse model of experimental endometriosis. Fertil Steril 95:1295-301.e1
Lebovic, Dan I; Mwenda, Jason M; Chai, Daniel C et al. (2010) Peroxisome proliferator-activated receptor-(gamma) receptor ligand partially prevents the development of endometrial explants in baboons: a prospective, randomized, placebo-controlled study. Endocrinology 151:1846-52
Shah, Divya K; Menon, K M J; Cabrera, Lourdes M et al. (2010) Thiazolidinediones decrease vascular endothelial growth factor (VEGF) production by human luteinized granulosa cells in vitro. Fertil Steril 93:2042-7
Kavoussi, S K; Witz, C A; Binkley, P A et al. (2009) Peroxisome-proliferator activator receptor-gamma activation decreases attachment of endometrial cells to peritoneal mesothelial cells in an in vitro model of the early endometriotic lesion. Mol Hum Reprod 15:687-92
Moravek, Molly B; Ward, Elizabeth A; Lebovic, Dan I (2009) Thiazolidinediones as therapy for endometriosis: a case series. Gynecol Obstet Invest 68:167-70
Kavoussi, Shahryar K; West, Brady T; Taylor, George W et al. (2009) Periodontal disease and endometriosis: analysis of the National Health and Nutrition Examination Survey. Fertil Steril 91:335-42
Medina, Melissa G; Lebovic, Dan I (2009) Endometriosis-associated nerve fibers and pain. Acta Obstet Gynecol Scand 88:968-75
Lebovic, Dan I; Mwenda, Jason M; Chai, Daniel C et al. (2007) PPAR-gamma receptor ligand induces regression of endometrial explants in baboons: a prospective, randomized, placebo- and drug-controlled study. Fertil Steril 88:1108-19

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