Candidate Background and Educational Plan: Michael S. Yi, MD, MSc, completed his internal medicine and pediatrics residency at Cincinnati Children's Hospital Medical Center (CCHMC) and the University of Cincinnati Medical Center (UCMC). He then completed his Outcomes Research Fellowship at the Institute for Health Policy and Health Services Research, and a Master of Science in Epidemiology at the Harvard School of Public Health, Boston. He recently joined the faculty at the University of Cincinnati College of Medicine with appointments in the Departments of Internal Medicine and Pediatrics. His division and department directors are strongly committed to fostering Dr. Yi's plans to examine the determinants of health outcomes and the value of health in adolescents with chronic illness. Joel Tsevat, MD, MPH, the project mentor, offers considerable content and methodologic expertise in the measurement of health-related quality of life and health values and has a K24 mentorship grant. The institution is committed to provide an environment that will support a didactic program that includes relevant courses in the behavioral and social sciences, advanced biostatistical methods, and research ethics, as well as interaction with other independent investigators from multiple disciplines. Research Plan: The primary objective of this proposal is to delineate the pathways underlying health values in adolescents with chronic illness.
The aims of this proposal are: 1) to determine the impact of inflammatory bowel disease (IBD) on health status, general health perceptions, well being, and health values; 2) to determine the differences in individual traits and perceptions and in the family and social environment of a general population of adolescents versus those living with IBD; and 3) to determine the relationships between developmental age, individual traits and perceptions, and family and social environment on the sense of overall well being and the value placed on health in a general population of adolescents and those living with IBD. The findings will inform on how both individual characteristics and structural and subjective family/social environmental factors impact health outcomes. It will break new ground in adolescent health values research by incorporating previously unstudied clinical, psychological, family, and environmental factors. Values/preferences methodology will be useful not only to assess health outcomes at a population level but also to assist individual-level health care decision-making; understanding the process by which young patients determine preferences/values will provide information for improving patient-centered health care delivery. The challenge and the major strength of this research agenda is its integration of behavioral and social science paradigms with clinical disease information.

Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Mentored Patient-Oriented Research Career Development Award (K23)
Project #
5K23HD044556-05
Application #
7478006
Study Section
Pediatrics Subcommittee (CHHD)
Program Officer
Haverkos, Lynne
Project Start
2004-09-17
Project End
2010-08-31
Budget Start
2008-09-01
Budget End
2010-08-31
Support Year
5
Fiscal Year
2008
Total Cost
$113,500
Indirect Cost
Name
University of Cincinnati
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
041064767
City
Cincinnati
State
OH
Country
United States
Zip Code
45221
Cotton, Sian; Humenay Roberts, Yvonne; Tsevat, Joel et al. (2010) Mind-body complementary alternative medicine use and quality of life in adolescents with inflammatory bowel disease. Inflamm Bowel Dis 16:501-6
Yi, Michael S; Britto, Maria T; Sherman, Susan N et al. (2009) Health values in adolescents with or without inflammatory bowel disease. J Pediatr 154:527-34
Cotton, Sian; Kudel, Ian; Roberts, Yvonne Humenay et al. (2009) Spiritual well-being and mental health outcomes in adolescents with or without inflammatory bowel disease. J Adolesc Health 44:485-92
Cotton, Sian; Grossoehme, Daniel; Rosenthal, Susan L et al. (2009) Religious/Spiritual coping in adolescents with sickle cell disease: a pilot study. J Pediatr Hematol Oncol 31:313-8
Mrus, Joseph M; Leonard, Anthony C; Yi, Michael S et al. (2006) Health-related quality of life in veterans and nonveterans with HIV/AIDS. J Gen Intern Med 21 Suppl 5:S39-47
Street, Natalie Jansen; Yi, Michael S; Bailey, Laurie A et al. (2006) Comparison of health-related quality of life between heterozygous women with Fabry disease, a healthy control population, and patients with other chronic disease. Genet Med 8:346-53
Mrus, Joseph M; Schackman, Bruce R; Wu, Albert W et al. (2006) Variations in self-rated health among patients with HIV infection. Qual Life Res 15:503-14
Mrus, Joseph M; Braun, LeeAnn; Yi, Michael S et al. (2005) Impact of HIV/AIDS on care and outcomes of severe sepsis. Crit Care 9:R623-30