Pelvic floor disorders (PFDs), including urinary incontinence, fecal incontinence, and pelvic organ prolapse, affect one-third of adult women. These conditions have a profound affect on quality-of-life, resulting in discomfort, embarrassment and functional limitations. In addition, up to 50% of women with PFDs report a problem with sexual function. However, it is unclear whether the sexual complaints of women with PFDs are attributable to PFDs or to other factors (i.e., relationship conflict or co-morbid conditions). Until recently, research on this subject has been hampered by the lack of survey instruments to assess female sexual dysfunction (FSD) and PFDs. ? ? Our research objective is to investigate the impact of PFDs on female sexual function. We hypothesize that PFDs are independently associated with FSD and that successful treatment of PFDs will restore sexual function. We propose two specific aims: (1) Using validated instruments, we will determine whether PFDs (urinary incontinence, fecal incontinence, and pelvic organ prolapse) are independently associated with sexual complaints and sexual dysfunction; and (2) among women with urinary or fecal incontinence treated with pelvic muscle physiotherapy, we will determine whether improvement in continence is associated with improvement in sexual function. ? ? The NICHD has given high priority to research that increases knowledge about human sexuality, including the impact of illness or disability. ? ? This proposal will improve our understanding of sexual function in women with PFDs. It will also serve as a foundation for further research on the impact of non-surgical and surgical interventions on the sexual function of women with PFDs. The proposed research will provide valuable research training and experience for the candidate. Career development during the award will include formal training in epidemiology, biostatistics, and clinical trial design at the Bloomberg School of Public Health. The environment at Johns Hopkins provides a strong infrastructure for clinical research and mentorship by experienced scientists. This powerful combination will provide the candidate with the necessary skills and experience to become a successful, independently funded investigator. ? ?

Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Mentored Patient-Oriented Research Career Development Award (K23)
Project #
5K23HD045806-03
Application #
7066069
Study Section
Pediatrics Subcommittee (CHHD)
Program Officer
Weber, Anne M
Project Start
2004-05-01
Project End
2008-04-30
Budget Start
2006-05-01
Budget End
2007-04-30
Support Year
3
Fiscal Year
2006
Total Cost
$131,410
Indirect Cost
Name
Johns Hopkins University
Department
Obstetrics & Gynecology
Type
Schools of Medicine
DUNS #
001910777
City
Baltimore
State
MD
Country
United States
Zip Code
21218
Handa, Victoria L; Whitcomb, Emily; Weidner, Alison C et al. (2011) Sexual function before and after non-surgical treatment for stress urinary incontinence. Female Pelvic Med Reconstr Surg 17:30-35
Knoepp, Leise R; Shippey, Stuart H; Chen, Chi Chiung Grace et al. (2010) Sexual complaints, pelvic floor symptoms, and sexual distress in women over forty. J Sex Med 7:3675-82
Quiroz, Lieschen H; Muñoz, Alvaro; Shippey, Stuart H et al. (2010) Vaginal parity and pelvic organ prolapse. J Reprod Med 55:93-8
Handa, Victoria L; Barber, Matthew D; Young, Stephen B et al. (2008) Paper versus web-based administration of the Pelvic Floor Distress Inventory 20 and Pelvic Floor Impact Questionnaire 7. Int Urogynecol J Pelvic Floor Dysfunct 19:1331-5
Gutman, Robert E; Ford, Daniel E; Quiroz, Lieschen H et al. (2008) Is there a pelvic organ prolapse threshold that predicts pelvic floor symptoms? Am J Obstet Gynecol 199:683.e1-7
Handa, Victoria L; Cundiff, Geoffrey; Chang, Howard H et al. (2008) Female sexual function and pelvic floor disorders. Obstet Gynecol 111:1045-52