This Mentored Patient-Oriented Research Career Development Award will prepare the applicant for a career in patient-oriented clinical research in the field of inborn errors of metabolism. Increased recognition and survival in children with metabolic disorders have created a great need for metabolic clinicians trained in clinical research. In particular the cognitive and behavioral profiles of children these children remain largely unexplored and worldwide few clinicians have the requisite skills and training to conduct these studies. The candidate plans to: 1) acquire didactic instruction in clinical research skills as well as familiarity with the fundamentals of cognition and neuropsychology, and 2) complete a mentored clinical research study on attentional dysfunction among children with phenylketonuria (PKU). The candidate's long-term goal is to develop a series of funded clinical investigations to improve biological and psychological outcomes in children with phenylketonuria and other inborn errors of metabolism. The University of Rochester School of Medicine and Dentistry provides a rich environment for conducting clinical research, and recently developed a formal curriculum for training candidates in clinical research. At the completion of the five-year period, the applicant will have the skills necessary to conduct funded clinical research, and the applicant's work will have the potential to contribute significantly to the body of patient-oriented clinical research in the field of inborn errors of metabolism.

Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Mentored Patient-Oriented Research Career Development Award (K23)
Project #
5K23HD046541-03
Application #
7076846
Study Section
Pediatrics Subcommittee (CHHD)
Program Officer
Kau, Alice S
Project Start
2004-06-07
Project End
2009-05-31
Budget Start
2006-06-01
Budget End
2007-05-31
Support Year
3
Fiscal Year
2006
Total Cost
$126,776
Indirect Cost
Name
University of Rochester
Department
Pediatrics
Type
Schools of Dentistry
DUNS #
041294109
City
Rochester
State
NY
Country
United States
Zip Code
14627
Arnold, Georgianne L; Van Hove, Johan; Freedenberg, Debra et al. (2009) A Delphi clinical practice protocol for the management of very long chain acyl-CoA dehydrogenase deficiency. Mol Genet Metab 96:85-90