This is a revised application for a K23 award for Dr. Henry Chong Lee, a neonatologist at the University of California, San Francisco. Dr. Lee is establishing himself as a young investigator in clinical research of quality improvement in neonatology. This K23 award will provide Dr. Lee with the support necessary to accomplish the following goals: (1) to become expert at survey and qualitative research methods;(2) to conduct clinical investigations of the factors influencing breast milk feeding in premature infants;(3) to gather data for the purpose of designing an intervention to promote breast milk feeding in premature infants;(4) to progress in leadership in quality improvement research in neonatology;and (5) to develop an independent clinical research career. To achieve these goals, Dr. Lee has assembled a mentoring team comprised of primary mentor Dr. R. Adams Dudley, Professor of Medicine and Health Policy at UCSF, a leader in largescale health services research;two co-mentors: Dr. Jeffrey Gould, a neonatologist and Professor at Stanford, a distinguished leader and researcher in quality improvement and Director of the California Perinatal Quality Care Collaborative, and Dr. Daniel Dohan, an expert in qualitative research methods in the Institute of Health Policy Studies at UCSF;and four scientific advisors: Dr. Jane Morton, an expert in breastfeeding and breast milk provision for premature infants, Dr. Yao Sun, Medical Director of the Division of Neonatology at UCSF and expert in information technology, who is concerned with patient safety and quality of care, Ralph Gonzales, Professor of Medicine and Epidemiology &Biostatics at UCSF, an expert in Implementation Sciences, and Dr. Anna N?poles, an expert in ethnic and racial disparities in medical care. Breast milk is established as the optimal feeding choice for premature infants as it prevents serious morbidities such as necrotizing enterocolitis. Nevertheless, many premature infants are not being fed breast milk by the time they are discharged home from the hospital. Breast milk provision for premature infants varies by socio-demographic and medical factors and varies widely by hospital. Dr. Lee's research will focus on the maternal, clinician, and hospital factors that impact breast milk feeding of premature infants. The results of his study will inform the design of an intervention to promote breast milk feeding in premature infants.
In Aim 1, Dr. Lee will perform a qualitative study using semi-structured interviews and a survey study of mothers to probe maternal factors related to pumping/feeding practices, focusing on the impact of early counseling and environmental factors.
In Aim 2, Dr. Lee will use a case study approach of high-performing and low-performing hospitals to determine what hospital factors impact breast milk feeding of premature infants.
In Aim 3, Dr. Lee will perform a statewide survey of more than 100 hospitals in California, in which he will study what clinical practices were associated with higher or lower rates of breast milk provision in premature infants. This research will form the basis for development of a pilot intervention to be proposed in an R03 grant application during the K award, and a subsequent multi-center intervention to promote breast milk feeding in premature infants, to be proposed in an R01 grant application at the end of the K award.

Public Health Relevance

Breast milk is the optimal feeding choice for premature infants but is often not provided due to difficulties in supporting a mother to pump breast milk for the duration of the infants'hospitalization. Understanding the maternal, clinician, and hospital factors that impact breast milk provision will lead to the design of interventions that can effectively promote this important practice.

National Institute of Health (NIH)
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Mentored Patient-Oriented Research Career Development Award (K23)
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Pediatrics Subcommittee (CHHD)
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Raiten, Daniel J
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Stanford University
Schools of Medicine
United States
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Lee, H C; Arora, V; Brown, T et al. (2017) Thematic analysis of barriers and facilitators to implementation of neonatal resuscitation guideline changes. J Perinatol 37:249-253
Ngo, Samantha; Profit, Jochen; Gould, Jeffrey B et al. (2017) Trends in Patent Ductus Arteriosus Diagnosis and Management for Very Low Birth Weight Infants. Pediatrics 139:
Robles, D; Blumenfeld, Y J; Lee, H C et al. (2017) Opportunities for maternal transport for delivery of very low birth weight infants. J Perinatol 37:32-35
Kantorowska, Agata; Wei, Julia C; Cohen, Ronald S et al. (2016) Impact of Donor Milk Availability on Breast Milk Use and Necrotizing Enterocolitis Rates. Pediatrics 137:e20153123
Wei, J C; Catalano, R; Profit, J et al. (2016) Impact of antenatal steroids on intraventricular hemorrhage in very-low-birth weight infants. J Perinatol 36:352-6
Lee, Henry C; Bennett, Mihoko V; Schulman, Joseph et al. (2016) Estimating Length of Stay by Patient Type in the Neonatal Intensive Care Unit. Am J Perinatol 33:751-7
Murphy, Daniel P; Lee, Henry C; Payton, Kurlen S E et al. (2016) Platelet count and associated morbidities in VLBW infants with pharmacologically treated patent ductus arteriosus. J Matern Fetal Neonatal Med 29:2045-8
Akula, V P; Gould, J B; Kan, P et al. (2016) Characteristics of neonatal transports in California. J Perinatol 36:1122-1127
Brown, Taylor; Tu, Joanna; Profit, Jochen et al. (2016) Optimal Criteria Survey for Preresuscitation Delivery Room Checklists. Am J Perinatol 33:203-7
Stone, Sohini; Lee, Henry C; Sharek, Paul J (2016) Perceived Factors Associated with Sustained Improvement Following Participation in a Multicenter Quality Improvement Collaborative. Jt Comm J Qual Patient Saf 42:309-15

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