Children with multiple sclerosis (MS) experience a high rate of cognitive impairment, with studies demonstrating cognitive dysfunction in up to half of children and adolescents affected by MS. Whether cognitive impairment relates to scholastic achievement in pediatric MS is currently not known. Dr. Vargas? K 23 proposal will assess the educational impact of multiple sclerosis in childhood. Dr. Vargas? goal is to become a clinical researcher with expertise in the cognitive, scholastic and functional outcomes of children with multiple sclerosis. Dr. Vargas will define the factors associated with poor academic achievement in children and teenagers with MS. Dr. Vargas?s goal is to assess whether cognitive impairment relates to academic impairment and to define the factors associated with academic and cognitive impairment in children with MS. This study will be the first study to evaluate academic achievement and related factors in children and adolescents with MS. Dr. Vargas will test her hypothesis that 1) children with MS will demonstrate academic deficiencies compared to their healthy peers, 2) there will be discordance between cognitive performance and academic performance in children with MS compared to healthy children, and 3) academic performance in children with MS will be related to psychosocial factors which may be intervened upon including mood, fatigue, sleep and social connectedness. This K23 award will provide Dr. Vargas the support needed to develop expertise in 3 major scientific areas: (1) Understanding the advantages and limitations of pediatric neuropsychological and academic testing; (2) Expertise in outcomes research methodology; (3) Mastery of advanced statistical techniques and their clinical application. Dr. Vargas will utilize her clinical-research training in the K23 to lead a multicenter study in New York City and Philadelphia to define the educational impact of childhood-onset multiple sclerosis. The ultimate goal is to identify modifiable variables related to scholastic achievement in children with MS and to target these variables in a large-scale future interventional trial of academic performance.

Public Health Relevance

Failure to complete high school is a significant public health problem, and limited data suggest that youth with multiple sclerosis (MS) discontinue school with high frequency. While it is known that cognitive impairment occurs frequently in children with MS, the functional impact of childhood MS on academic outcomes is almost completely unknown. Identifying whether cognitive performance affects academic performance in children with MS, and defining the clinical features associated with poor scholastic achievement in this group, is essential as these children have many years of formative education remaining, and this work will lead to areas of specific, targeted interventions to improve academic performance.

Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Mentored Patient-Oriented Research Career Development Award (K23)
Project #
5K23HD098312-02
Application #
9954126
Study Section
National Institute of Child Health and Human Development Initial Review Group (CHHD)
Program Officer
Griffin, James
Project Start
2019-06-13
Project End
2022-05-31
Budget Start
2020-06-01
Budget End
2021-05-31
Support Year
2
Fiscal Year
2020
Total Cost
Indirect Cost
Name
Columbia University (N.Y.)
Department
Neurology
Type
Schools of Medicine
DUNS #
621889815
City
New York
State
NY
Country
United States
Zip Code
10032