The candidate has completed residency training, a Chief Residency and a fellowship in cardiology at Massachusetts General Hospital (MGH), as well as a research fellowship at the Framingham Heart Study. During that time, he began formal didactic training in clinical research methods at the Harvard School of Public Health, and he has published several first-author manuscripts in major journals. He is now on staff in the Cardiology Division at MGH with a faculty appointment at Harvard Medical School. The candidate seeks to pursue a career as a clinician-scientist, treating cardiology patients as a consultant cardiologist for 25% of his time commitment, with an emphasis on preventive cardiology, while devoting 75% of his time to developing the skills needed to become an excellent epidemiologist and researcher in cardiovascular diseases. Within this larger framework, the proposed project will further the career goals of the candidate in both the short- and long-term. Using previously acquired and new data from the Framingham Heart Study, the candidate proposes to examine the lifetime risks of atherosclerotic cardiovascular diseases and congestive heart failure. Lifetime risk data, which are more easily understood by the general public than other measures of risk, may be useful to clinicians and policy-makers in increasing public health efforts at prevention of cardiovascular diseases, which remain the major cause of morbidity and mortality in the United States. Further work is also needed to examine differences in lifetime risk associated with different risk factor strata (e.g. smokers versus non-smokers). It is anticipated that during the period of this award, the candidate will gain the skills required to address these and other questions using the most appropriate data management and statistical techniques. Through a combination of didactic courses at the Harvard School of Public Health, participation in ongoing data collection at the Framingham Study, and experience with statistical programming under the guidance of the experienced mentor and collaborators, the candidate plans to develop the skills necessary to complete the proposed project and to provide the basis for a successful career as a cardiovascular researcher.

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Mentored Patient-Oriented Research Career Development Award (K23)
Project #
5K23HL004253-03
Application #
6615610
Study Section
Special Emphasis Panel (ZHL1-CSR-F (F1))
Program Officer
Sorlie, Paul
Project Start
2001-08-10
Project End
2003-12-31
Budget Start
2003-08-01
Budget End
2003-12-31
Support Year
3
Fiscal Year
2003
Total Cost
$33,514
Indirect Cost
Name
Massachusetts General Hospital
Department
Type
DUNS #
073130411
City
Boston
State
MA
Country
United States
Zip Code
02199
Lloyd-Jones, Donald M; Dyer, Alan R; Wang, Renwei et al. (2007) Risk factor burden in middle age and lifetime risks for cardiovascular and non-cardiovascular death (Chicago Heart Association Detection Project in Industry). Am J Cardiol 99:535-40
Lloyd-Jones, Donald M; Leip, Eric P; Larson, Martin G et al. (2006) Prediction of lifetime risk for cardiovascular disease by risk factor burden at 50 years of age. Circulation 113:791-8
Allen, Larry A; O'Donnell, Christopher J; Camargo Jr, Carlos A et al. (2006) Comparison of long-term mortality across the spectrum of acute coronary syndromes. Am Heart J 151:1065-71
Lloyd-Jones, Donald M; Evans, Jane C; Levy, Daniel (2005) Hypertension in adults across the age spectrum: current outcomes and control in the community. JAMA 294:466-72
Lloyd-Jones, Donald M; Leip, Eric P; Larson, Martin G et al. (2005) Novel approach to examining first cardiovascular events after hypertension onset. Hypertension 45:39-45
Fox, Caroline S; Parise, Helen; D'Agostino Sr, Ralph B et al. (2004) Parental atrial fibrillation as a risk factor for atrial fibrillation in offspring. JAMA 291:2851-5
Lloyd-Jones, Donald M; Wilson, Peter W F; Larson, Martin G et al. (2004) Framingham risk score and prediction of lifetime risk for coronary heart disease. Am J Cardiol 94:20-4
Allen, Larry A; O'Donnell, Christopher J; Giugliano, Robert P et al. (2004) Care concordant with guidelines predicts decreased long-term mortality in patients with unstable angina pectoris and non-ST-elevation myocardial infarction. Am J Cardiol 93:1218-22
Lloyd-Jones, Donald M; Wang, Thomas J; Leip, Eric P et al. (2004) Lifetime risk for development of atrial fibrillation: the Framingham Heart Study. Circulation 110:1042-6
Lloyd-Jones, Donald M; Nam, Byung-Ho; D'Agostino Sr, Ralph B et al. (2004) Parental cardiovascular disease as a risk factor for cardiovascular disease in middle-aged adults: a prospective study of parents and offspring. JAMA 291:2204-11

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