Traditionally, evaluation of patients with suspected coronary artery disease has focused on the epicardial coronary system. More recently, investigators have come to appreciate better that the status of the coronary microcirculation can influence significantly long-term morbidity and mortality. Although cardiac transplant recipients commonly develop microcirculatory dysfunction, its timing and its effect on outcomes is unclear. Patients with acute myocardial infarction, despite successful recanalization of an occluded epicardial artery, suffer from microcirculatory dysfunction, both in the infarcted region, as well as in myocardium remote from the infarction. However, the incidence and implications of micro-circulatory dysfunction in areas remote from an acutely infarcted territory are poorly understood. To date, evaluation of the coronary microcirculation has been limited by techniques which incorporate the epicardial system into their assessment. Additionally, most methods require specialized equipment and/or analyses. Others are limited by their qualitative nature. Finally, the majority of methods are noninvasive, yet many patients first present for evaluation of their coronary arterial system in the cardiac catheterization laboratory. The first goal of this project is to demonstrate that an invasive, coronary wire-based method for evaluating the coronary microcirculation is easy to perform and interpret, quantitative, and correlates well with standard methods for assessing the microcirculation. The technique will be validated in a porcine model of epicardial artery and microcirculatory disease. It's correlation with PET imaging, the current gold standard noninvasive method of evaluating the microcirculation, will then be tested in patients with and without microcirculatory dysfunction. The second and third goals of this study will be to apply this technique to gain a better understanding of the role of the microcirculation in the outcomes of cardiac transplant patients and those suffering from acute myocardial infarction.

National Institute of Health (NIH)
National Heart, Lung, and Blood Institute (NHLBI)
Mentored Patient-Oriented Research Career Development Award (K23)
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Special Emphasis Panel (ZHL1-CSR-J (O1))
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Scott, Jane
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Stanford University
Internal Medicine/Medicine
Schools of Medicine
United States
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Kitahara, Hideki; Okada, Kozo; Tanaka, Shigemitsu et al. (2016) Association of periarterial neovascularization with progression of cardiac allograft vasculopathy and long-term clinical outcomes in heart transplant recipients. J Heart Lung Transplant 35:752-9
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Haddad, Fran├žois; Khazanie, Prateeti; Deuse, Tobias et al. (2012) Clinical and functional correlates of early microvascular dysfunction after heart transplantation. Circ Heart Fail 5:759-68
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Sakurai, Ryota; Yamasaki, Masao; Nakamura, Mamoo et al. (2007) Determinants of lumen loss between years 1 and 2 after cardiac transplantation. Transplantation 84:1097-102
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Fearon, William F; Potena, Luciano; Hirohata, Atsushi et al. (2007) Changes in coronary arterial dimensions early after cardiac transplantation. Transplantation 83:700-5
Fearon, William F (2006) Physiologic assessment of renal artery stenosis: will history repeat itself? J Am Coll Cardiol 48:1856-8

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