This K23 application is a request to enable Dr. Daichi Shimbo to develop into an independent, translational researcher with expertise in preventive cardiology. He has training in cardiology and has had some previous experience in conducting basic science research, but lacks some fundamental skills that would allow him to become an independent researcher in this field. His short-term goals are to strengthen his theoretical, methodological, and statistical skills in clinical trials, in the basic sciences, and in preventive cardiology. His long-term goals are to develop an independent lab funded by external sources, to train and mentor future clinical researchers, and to develop a network of research scientists devoted to preventive cardiology. This award will aid Dr. Shimbo in attaining his short- and long-term goals by providing time and resources for him to acquire knowledge and expertise in the following five modules: (1) clinical trials design, (2) statistics, (3) basic science methodology relevant to patient-oriented research, (4) preventive cardiology, and (5) medical research dissemination. The NIH-sponsored K30 Research Curriculum, the Integrative & Behavioral Cardiology Program, and the Cardiovascular Biology Research Laboratory make Mount Sinai School of Medicine an ideal environment for this training. Dr. Thomas Pickering is an ideal sponsor of this award because of his world-renowned expertise in preventive cardiology. Because established risk factors do not account for all patients who develop the acute coronary syndromes (ACS), the search for """"""""non-classic"""""""" risk factors has emerged. Evidence suggests that one such factor, hostility, independently predicts ACS events. The exact biological mechanisms underlying the hostility-ACS link have not been elucidated. Inflammation and platelets play central roles in the development of the ACS, and thus hostility may increase ACS risk through the inflammation and platelet-thrombosis pathways. The goals of the proposed research program are (1) to examine whether higher levels of hostility are associated with increased levels of inflammatory markers and platelet reactivity, and (2) to examine whether hostility reduction decreases levels of inflammatory markers and platelet reactivity. Data from this translational research program will allow Dr. Shimbo to establish an empirical foundation from which to apply these data to the development of effective preventive interventions for hostile patients.

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Mentored Patient-Oriented Research Career Development Award (K23)
Project #
5K23HL072866-04
Application #
6901133
Study Section
Special Emphasis Panel (ZHL1-CSR-J (F1))
Program Officer
Scott, Jane
Project Start
2003-07-01
Project End
2008-06-30
Budget Start
2005-07-01
Budget End
2006-06-30
Support Year
4
Fiscal Year
2005
Total Cost
$154,845
Indirect Cost
Name
Columbia University (N.Y.)
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
621889815
City
New York
State
NY
Country
United States
Zip Code
10032
Rom Korin, Maya; Chaplin, William F; Shaffer, Jonathan A et al. (2013) Men's and women's health beliefs differentially predict coronary heart disease incidence in a population-based sample. Health Educ Behav 40:231-9
Shaffer, Jonathan A; Wasson, Lauren Taggart; Davidson, Karina W et al. (2012) Blood Pressure Reactivity to an Anger Provocation Interview Does Not Predict Incident Cardiovascular Disease Events: The Canadian Nova Scotia Health Survey (NSHS95) Prospective Population Study. Int J Hypertens 2012:658128
Newman, Jonathan D; Davidson, Karina W; Shaffer, Jonathan A et al. (2011) Observed hostility and the risk of incident ischemic heart disease: a prospective population study from the 1995 Canadian Nova Scotia Health Survey. J Am Coll Cardiol 58:1222-8
Hasegawa, Takuya; Boden-Albala, Bernadette; Eguchi, Kazuo et al. (2010) Impaired flow-mediated vasodilatation is associated with increased left ventricular mass in a multiethnic population. The Northern Manhattan Study. Am J Hypertens 23:413-9
Davidson, Karina W; Mostofsky, Elizabeth (2010) Anger expression and risk of coronary heart disease: evidence from the Nova Scotia Health Survey. Am Heart J 159:199-206
Rosenberg, Leah B; Whang, William; Shimbo, Daichi et al. (2010) Exposure to tricyclic antidepressants is associated with an increased risk of incident CHD events in a population-based study. Int J Cardiol 145:124-5
Shimbo, Daichi; Kuruvilla, Sujith; Haas, Donald et al. (2009) Preventing misdiagnosis of ambulatory hypertension: algorithm using office and home blood pressures. J Hypertens 27:1775-83
Shimbo, Daichi; Chaplin, William; Kuruvilla, Sujith et al. (2009) Hostility and platelet reactivity in individuals without a history of cardiovascular disease events. Psychosom Med 71:741-7
Davidson, Karina W; Schwartz, Joseph E; Kirkland, Susan A et al. (2009) Relation of inflammation to depression and incident coronary heart disease (from the Canadian Nova Scotia Health Survey [NSHS95] Prospective Population Study). Am J Cardiol 103:755-61
Kronish, Ian M; Rieckmann, Nina; Schwartz, Joseph E et al. (2009) Is depression after an acute coronary syndrome simply a marker of known prognostic factors for mortality? Psychosom Med 71:697-703

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