Candidate: James M. O'Brien, Jr., MD is committed to becoming an independent researcher in critical care health services research with interests in patient-oriented outcomes and processes of care. His background includes a strong foundation in academic medicine, excellent training in pulmonary and critical care medicine, and scholarly work applicable to his future research plans. His talents combine a passion for providing high quality care to ICU patients with a driving interest to study the processes of provided care and to expand the repertoire of outcome measures used to evaluate critically ill patients. The K23 career development award will provide the time and support required for him to continue his training and advance his research objectives. Environment: The mentorship and institutional resources available to Dr. O'Brien create a unique environment for the nurturing of a career in a relatively novel field: critical care health services research. Andrew Kramer, MD (sponsor) and Carolyn Welsh, MD (co-sponsor) bring the complementary talents of expertise in health service research and clinical critical care research, respectively, to provide the candidate with support that crosses traditional boundaries of patient-oriented research. The candidate's appointment is through the Division of Pulmonary Science and Critical Care Medicine at the University of Colorado Health Sciences Center although he will continue to benefit from the resources of the Division of Health Care Policy and Research. Research: The global ambition of the proposed studies is to better understand the role of excess body weight as a risk factor for worse outcomes from critical illness and for substandard ICU care (as determined by process measures). A prospective, observational, cohort study will explore the influence of obesity on (1) short-term clinical outcomes (number of ventilator-free days); (2) resource utilization (ICU length of stay); (3) long-term survival; and (4) patient-oriented outcome measures (health-related quality of life). In this study, we will also attend to process measures (duration of """"""""weaning"""""""" from mechanical ventilation and TISS-28 scores) as a surrogate for the quality of care. These studies will describe the effect of excess body weight on critical illness and produce a new type of independent investigator - the ICU health services researcher.

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Mentored Patient-Oriented Research Career Development Award (K23)
Project #
5K23HL075076-03
Application #
7198036
Study Section
Special Emphasis Panel (ZHL1-CSR-Q (F3))
Program Officer
Scott, Jane
Project Start
2005-04-15
Project End
2009-03-31
Budget Start
2007-04-01
Budget End
2008-03-31
Support Year
3
Fiscal Year
2007
Total Cost
$130,248
Indirect Cost
Name
Ohio State University
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
832127323
City
Columbus
State
OH
Country
United States
Zip Code
43210
O'Brien Jr, James M; Philips, Gary S; Ali, Naeem A et al. (2012) The association between body mass index, processes of care, and outcomes from mechanical ventilation: a prospective cohort study. Crit Care Med 40:1456-63
O'Brien Jr, James M; Lu, Bo; Ali, Naeem A et al. (2011) Insurance type and sepsis-associated hospitalizations and sepsis-associated mortality among US adults: a retrospective cohort study. Crit Care 15:R130
O'Brien Jr, James M; Aberegg, Scott K; Ali, Naeem A et al. (2010) Results from the National Sepsis Practice Survey: use of drotrecogin ? (activated) and other therapeutic decisions. J Crit Care 25:658.e7-15
Prescott, Hallie C; O'Brien, James M (2010) Prevention of ventilator-associated pneumonia in adults. F1000 Med Rep 2:
McCallister, Jennifer W; Adkins, Eric J; O'Brien Jr, James M (2009) Obesity and acute lung injury. Clin Chest Med 30:495-508, viii
O'Brien Jr, James M; Aberegg, Scott K; Ali, Naeem A et al. (2009) Results from the national sepsis practice survey: predictions about mortality and morbidity and recommendations for limitation of care orders. Crit Care 13:R96
O'Brien Jr, James M; Lu, Bo; Ali, Naeem A et al. (2007) Alcohol dependence is independently associated with sepsis, septic shock, and hospital mortality among adult intensive care unit patients. Crit Care Med 35:345-50
Baran, Christopher P; Opalek, Judy M; McMaken, Sara et al. (2007) Important roles for macrophage colony-stimulating factor, CC chemokine ligand 2, and mononuclear phagocytes in the pathogenesis of pulmonary fibrosis. Am J Respir Crit Care Med 176:78-89
Ezzie, Michael E; Aberegg, Scott K; O'Brien Jr, James M (2007) Laboratory testing in the intensive care unit. Crit Care Clin 23:435-65
O'Brien Jr, James M; Phillips, Gary S; Ali, Naeem A et al. (2006) Body mass index is independently associated with hospital mortality in mechanically ventilated adults with acute lung injury. Crit Care Med 34:738-44