? ? Alka Kanaya is Assistant Professor of Medicine at the University of California, San Francisco, in the Division of General Internal Medicine. Her long-term career goal is to develop a prospective population-based cohort of South Asian adults to examine the antecedants of clinical cardiovascular disease responsible for the disparately high rates of disease in this understudied population. Under the mentorship of Drs. Stephen Hulley and Morris Schambelan, Dr. Kanaya proposes a comprehensive multidisciplinary career development plan composed of genetic epidemiology and advanced statistical coursework, two separate clinical research apprenticeships in the fields of glucose and lipid metabolism and genetic studies, and practical cohort management experience. The research plan, titled the Metabolic Syndrome and Atherosclerosis in South Asians Living in America (MASALA), is a cross-sectional study of a community-based sample of South Asians to determine whether insulin resistance, the metabolic syndrome, body fat distribution, adipocytokines, lipid subtractions, and thrombosis factors are independently associated with subclinical atherosclerosis. This study is modeled on an ongoing National Heart Lung and Blood Institute study (the Multi-Ethnic Study of Atherosclerosis) with identical sampling methods, eligibility criteria, lab assays and atherosclerosis measures to allow for efficient comparisons across multiple ethnic groups. The study will recruit 150 South Asians between the ages of 55 and 84 without cardiovascular disease. Eligible participants will attend a General Clinical Research Center for a 6-hour visit to undergo fasting blood tests, frequently sampled intravenous glucose tolerance test, questionnaire, body anthropometry, blood pressure, whole body DEXA, carotid ultrasound, and cardiac and abdominal CT scan. Objectives of this study are to: (1) determine the prevalence of insulin resistance (IR), the metabolic syndrome, and atherosclerosis among ? South Asians; (2) test the hypotheses that visceral adiposity and adipocytokines are associated with IR, and that IR, lipid subfractions, and a thrombosis marker are associated with atherosclerosis independent of traditional cardiac risk factors; and (3) test the hypotheses that South Asians have higher prevalence of metabolic features and atherosclerosis compared with other ethnic groups enrolled in MESA, and that IR and metabolic factors explain the increased prevalence of atherosclerosis in South Asians. (End of Abstract) ? ?

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Mentored Patient-Oriented Research Career Development Award (K23)
Project #
1K23HL080026-01A1
Application #
7016226
Study Section
Special Emphasis Panel (ZHL1-CSR-M (O1))
Program Officer
Wei, Gina
Project Start
2006-03-01
Project End
2009-02-28
Budget Start
2006-03-01
Budget End
2007-02-28
Support Year
1
Fiscal Year
2006
Total Cost
$147,182
Indirect Cost
Name
University of California San Francisco
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
094878337
City
San Francisco
State
CA
Country
United States
Zip Code
94143
Al Rifai, Mahmoud; Cainzos-Achirica, Miguel; Kanaya, Alka M et al. (2018) Discordance between 10-year cardiovascular risk estimates using the ACC/AHA 2013 estimator and coronary artery calcium in individuals from 5 racial/ethnic groups: Comparing MASALA and MESA. Atherosclerosis 279:122-129
Bhupathiraju, Shilpa N; Guasch-Ferré, Marta; Gadgil, Meghana D et al. (2018) Dietary Patterns among Asian Indians Living in the United States Have Distinct Metabolomic Profiles That Are Associated with Cardiometabolic Risk. J Nutr 148:1150-1159
Chiang, Janet M; Stanczyk, Frank Z; Kanaya, Alka M (2018) Vitamin D Levels, Body Composition, and Metabolic Factors in Asian Indians: Results from the Metabolic Syndrome and Atherosclerosis in South Asians Living in America Pilot Study. Ann Nutr Metab 72:223-230
Shah, Arti D; Schmidt, Heidi; Sen, Saunak et al. (2015) The association between body composition and cystatin C in South Asians: results from the MASALA study. Obes Res Clin Pract 9:180-3
Needham, B L; Kim, C; Mukherjee, B et al. (2015) Endogenous sex steroid hormones and glucose in a South-Asian population without diabetes: the Metabolic Syndrome and Atherosclerosis in South-Asians Living in America pilot study. Diabet Med 32:1193-200
Kim, Catherine; Kong, Shengchun; Krauss, Ronald M et al. (2015) Endogenous Sex Steroid Hormones, Lipid Subfractions, and Ectopic Adiposity in Asian Indians. Metab Syndr Relat Disord 13:445-52
Flowers, Elena; Gadgil, Meghana; Aouizerat, Bradley E et al. (2015) Circulating micrornas associated with glycemic impairment and progression in Asian Indians. Biomark Res 3:22
Gujral, Unjali P; Narayan, K M Venkat; Kahn, Steven E et al. (2014) The relative associations of ?-cell function and insulin sensitivity with glycemic status and incident glycemic progression in migrant Asian Indians in the United States: the MASALA study. J Diabetes Complications 28:45-50
Gadgil, Meghana D; Anderson, Cheryl A M; Kandula, Namratha R et al. (2014) Dietary patterns in Asian Indians in the United States: an analysis of the metabolic syndrome and atherosclerosis in South Asians Living in America study. J Acad Nutr Diet 114:238-43
Mukherjea, Arnab; Underwood, Kelsey Clark; Stewart, Anita L et al. (2013) Asian Indian views on diet and health in the United States: importance of understanding cultural and social factors to address disparities. Fam Community Health 36:311-23

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