This K23 Mentored Patient Oriented Clinical Research Development Award application outlines a program of research to study modifiable risk factors for chronic posttraumatic stress disorder in urban, inner-city adolescents exposed to community violence. The career development and research plans are designed for the candidate to obtain training in the methodology of longitudinal data collection, the identification of risk factors for chronic PTSD, and an opportunity to incorporate psychophysiological types of assessment into studies of traumatized adolescents. The candidate is an Assistant Professor of Psychiatry and Child Psychiatry at Yale University School of Medicine (YUSM) with a clinical background in pediatrics, psychiatry and advanced clinical training in child psychiatry. Dr Steven Southwick, Program Co-Director of the Clinical Neuroscience Division of the National Center for Posttraumatic Stress Disorder and a Professor of Psychiatry at YUSM will serve as the candidate's Mentor. Preceptors at YUSM include Dr Carolyn Mazure, Dr Linda Mayes and Dr Walter Anyan. Dr Robert Pynoos, Professor of Psychiatry at UCLA, who directs the UCLA trauma program will act as a child trauma consultant and Dr Paul Maciejewskis will provide biostatistical consultation to the project. In the proposed research program, the candidate will conduct a multi-modal, baseline assessment and follow up assessments at three time points over two years of 150 inner-city adolescents, recruited from a hospital-and four school-based primary care clinics who, within the proceeding three months, have experienced an episode of community violence that meets DSM-IV defined, Criterion A stressor requirements. This project will examine the moderating effect of three potential modifiable risk factors (social support, family function, and types of coping skills) for the development of chronic, persistent PTSD. In addition, the project will track other psychopathology, psychosocial functioning, intervening traumas, behavioral outcomes (substance use, teen pregnancies, school attendance, arrest rates and medical treatment utilization) in this cohort of urban, inner- city adolescents. A psychophysiological assessment of hyper arousal will examine the role of acoustic startle responses as an objective marker of hyper arousal symptoms in this population.

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Mentored Patient-Oriented Research Career Development Award (K23)
Project #
5K23MH001789-03
Application #
6499209
Study Section
Special Emphasis Panel (ZMH1-CRB-H (01))
Program Officer
Price, Leshawndra N
Project Start
2000-02-01
Project End
2005-01-31
Budget Start
2002-02-01
Budget End
2003-01-31
Support Year
3
Fiscal Year
2002
Total Cost
$146,381
Indirect Cost
Name
Yale University
Department
Psychiatry
Type
Schools of Medicine
DUNS #
082359691
City
New Haven
State
CT
Country
United States
Zip Code
06520
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Grasso, Damion; Boonsiri, Joseph; Lipschitz, Deborah et al. (2009) Posttraumatic stress disorder: the missed diagnosis. Child Welfare 88:157-76
Lipschitz, Deborah S; Mayes, Linda M; Rasmusson, Ann M et al. (2005) Baseline and modulated acoustic startle responses in adolescent girls with posttraumatic stress disorder. J Am Acad Child Adolesc Psychiatry 44:807-14
Lipschitz, Deborah S; Rasmusson, Ann M; Yehuda, Rachel et al. (2003) Salivary cortisol responses to dexamethasone in adolescents with posttraumatic stress disorder. J Am Acad Child Adolesc Psychiatry 42:1310-7
Lipschitz, Deborah S; Rasmusson, Ann M; Anyan, Walter et al. (2003) Posttraumatic stress disorder and substance use in inner-city adolescent girls. J Nerv Ment Dis 191:714-21