Obsessive-compulsive disorder (OCD) is a disabling illness with a lifetime prevalence as high as 2-3 percent. This K23 application proposes a program of career development and research that will help the P.I. achieve her long-term goal: to improve the outcome of patients with OCD. The program will be carried out under the mentorship of Dr. Michael Liebowitz and in collaboration with Drs. Edna Foa, Marc Laruelle, and other preceptors (Drs. Donald Klein, Jean Endicott, David Pauls, Scott Rauch, Paul Greene, and Eva Petkova). The training program is designed so that the P.I. will: 1) develop expertise in the phenomenology and treatment of OCD (by receiving expert supervision in the evaluation and treatment of OCD patients, advanced training in psychopharmacological treatment and cognitive-behavioral therapy using exposure and ritual prevention (EX/RP), and specialized training in tic disorders); 2) acquire the skills and experiences needed by an independent clinical researcher (by coursework/supervision in research design, multivariate statistics, outcome measures, and ethics and by conducting several research projects, including a large clinical trial); and 3) be able to collaborate effectively with brain imaging experts (by learning about state-of-the-art imaging methods and helping to conduct an OCD brain imaging project using MRI and PET technology). The research component will consist of three complementary projects: 1) the assessment of residual clinical symptoms and of functional and neurocognitive impairments in a large sample of treated OCD patients; 2) a randomized controlled trial to examine the efficacy of adjunctive EX/RP for augmenting serotonin reuptake inhibitors in OCD; and 3) the measurement of the serotonin transporter in OCD patients and normal controls (using a radiolabeled ligand and PET) to examine whether there are specific serotonergic abnormalities in the brains of OCD patients. The long-term goal of this work is to improve the outcome of patients with OCD.

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Mentored Patient-Oriented Research Career Development Award (K23)
Project #
5K23MH001907-04
Application #
6638897
Study Section
Special Emphasis Panel (ZMH1-ITV-D (01))
Program Officer
Light, Enid
Project Start
2000-07-07
Project End
2005-06-30
Budget Start
2003-07-01
Budget End
2004-06-30
Support Year
4
Fiscal Year
2003
Total Cost
$170,823
Indirect Cost
Name
Columbia University (N.Y.)
Department
Psychiatry
Type
Schools of Medicine
DUNS #
621889815
City
New York
State
NY
Country
United States
Zip Code
10032
Strauss, Asher Y; Huppert, Jonathan D; Simpson, H Blair et al. (2018) What matters more? Common or specific factors in cognitive behavioral therapy for OCD: Therapeutic alliance and expectations as predictors of treatment outcome. Behav Res Ther 105:43-51
Farris, Samantha G; McLean, Carmen P; Van Meter, Page E et al. (2013) Treatment response, symptom remission, and wellness in obsessive-compulsive disorder. J Clin Psychiatry 74:685-90
Foa, Edna B; Simpson, Helen Blair; Liebowitz, Michael R et al. (2013) Six-month follow-up of a randomized controlled trial augmenting serotonin reuptake inhibitor treatment with exposure and ritual prevention for obsessive-compulsive disorder. J Clin Psychiatry 74:464-9
Maher, M J; Huppert, J D; Chen, H et al. (2010) Moderators and predictors of response to cognitive-behavioral therapy augmentation of pharmacotherapy in obsessive-compulsive disorder. Psychol Med 40:2013-23
Huppert, Jonathan D; Simpson, H Blair; Nissenson, Kore J et al. (2009) Quality of life and functional impairment in obsessive-compulsive disorder: a comparison of patients with and without comorbidity, patients in remission, and healthy controls. Depress Anxiety 26:39-45
Simpson, Helen Blair; Petkova, Eva; Cheng, Jianfeng et al. (2008) Statistical choices can affect inferences about treatment efficacy: a case study from obsessive-compulsive disorder research. J Psychiatr Res 42:631-8
Simpson, Helen Blair; Foa, Edna B; Liebowitz, Michael R et al. (2008) A randomized, controlled trial of cognitive-behavioral therapy for augmenting pharmacotherapy in obsessive-compulsive disorder. Am J Psychiatry 165:621-30
Simpson, Helen Blair; Huppert, Jonathan D; Petkova, Eva et al. (2006) Response versus remission in obsessive-compulsive disorder. J Clin Psychiatry 67:269-76
Simpson, Helen Blair; Rosen, Wilma; Huppert, Jonathan D et al. (2006) Are there reliable neuropsychological deficits in obsessive-compulsive disorder? J Psychiatr Res 40:247-57
Simpson, H Blair; Lombardo, Ilise; Slifstein, Mark et al. (2003) Serotonin transporters in obsessive-compulsive disorder: a positron emission tomography study with [(11)C]McN 5652. Biol Psychiatry 54:1414-21