The primary career development goal of this proposal is to provide the candidate with additional supervised experience and training in order to become an independent patient-oriented scientist. Through a multidisciplinary didactic structured training program, the candidate will obtain the basic knowledge and research skills necessary for an independent research career in child mental health. The candidate will participate in graduate course work in the School of Medicine Departments of Physiology, Radiology, Neuroscience and Health Care Policy and Research. The primary research goal is to conduct a project that will focus on the candidate's academic interest: the effects of environmental stress on the developing brain. Through this project, the candidate also will acquire experience in advanced research methods that will be necessary for an independent academic career in the future. Through the study of traumatic stress, such as child maltreatment, on early development the candidate will shed light into the dynamic mechanisms that occur in early development and that shape later behavior. Accordingly, an important objective of the proposed research project is to become knowledgeable and skilled in the field of functional neuroanatomy as a means to integrate prior and current leading methodologies in the field of traumatic stress. To this effect, the proposed research project has the following specific aims: a) to improve our understanding of neurobehavioral and cognitive outcome in children at risk for PTSD; b) to elucidate the role of the limbic-hypothalamic-pituitary-adrenal (LHPA) axis in the pathogenesis of PTSD; c) to enhance our knowledge of the Autonomic Nervous System (ANS) in pediatric PTSD; and d) to utilize functional brain imaging in children with PTSD to identify the specific neurofunctional systems underlying associated cognitive and behavioral abnormalities.

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Mentored Patient-Oriented Research Career Development Award (K23)
Project #
5K23MH063893-04
Application #
6761808
Study Section
Special Emphasis Panel (ZRG1-BBBP-2 (01))
Program Officer
Boyce, Cheryl A
Project Start
2001-08-17
Project End
2006-07-31
Budget Start
2004-08-01
Budget End
2005-07-31
Support Year
4
Fiscal Year
2004
Total Cost
$174,625
Indirect Cost
Name
Stanford University
Department
Psychiatry
Type
Schools of Medicine
DUNS #
009214214
City
Stanford
State
CA
Country
United States
Zip Code
94305
Weems, Carl F; Klabunde, Megan; Russell, Justin D et al. (2015) Post-traumatic stress and age variation in amygdala volumes among youth exposed to trauma. Soc Cogn Affect Neurosci 10:1661-7
Wong, Shane Shucheng; Kletter, Hilit; Wong, Yukwal et al. (2013) A prospective study on the association between caregiver psychological symptomatology and symptom clusters of pediatric posttraumatic stress disorder. J Trauma Stress 26:385-91
Garrett, Amy S; Carrion, Victor; Kletter, Hilit et al. (2012) Brain activation to facial expressions in youth with PTSD symptoms. Depress Anxiety 29:449-59
Burke, Nadine J; Hellman, Julia L; Scott, Brandon G et al. (2011) The impact of adverse childhood experiences on an urban pediatric population. Child Abuse Negl 35:408-13
Carrion, Victor G; Weems, Carl F; Richert, Kit et al. (2010) Decreased prefrontal cortical volume associated with increased bedtime cortisol in traumatized youth. Biol Psychiatry 68:491-3
Carrión, Victor G; Haas, Brian W; Garrett, Amy et al. (2010) Reduced hippocampal activity in youth with posttraumatic stress symptoms: an FMRI study. J Pediatr Psychol 35:559-69
Weems, Carl F; Carrión, Victor G (2009) Brief report: diurnal salivary cortisol in youth--clarifying the nature of posttraumatic stress dysregulation. J Pediatr Psychol 34:389-95
Carrion, Victor G; Weems, Carl F; Watson, Christa et al. (2009) Converging evidence for abnormalities of the prefrontal cortex and evaluation of midsagittal structures in pediatric posttraumatic stress disorder: an MRI study. Psychiatry Res 172:226-34
Kletter, Hilit; Weems, Carl F; Carrion, Victor G (2009) Guilt and posttraumatic stress symptoms in child victims of interpersonal violence. Clin Child Psychol Psychiatry 14:71-83
Carrion, Victor G; Garrett, Amy; Menon, Vinod et al. (2008) Posttraumatic stress symptoms and brain function during a response-inhibition task: an fMRI study in youth. Depress Anxiety 25:514-26

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