This application requests a Mentored Patient-Oriented Research Career Development Award (K23). The candidate is a geriatric psychiatrist and postdoctoral research fellow at the University of Pittsburgh who proposes to develop research skills for geriatric psychiatry research in medical rehabilitation settings. Funding of this award would provide time and resources necessary for him to develop into an independent investigator capable of conducting depression intervention studies in elderly patients undergoing rehabilitation after disabling medical events such as hip fracture. Studies of elders undergoing rehabilitation suggest that depression is associated with poorer outcomes and an increased likelihood of permanent disability and institutionalization. Therefore, it would be of tremendous public health benefit to determine the most efficacious interventions for late-life depression in the medical rehabilitation setting. However, little such intervention research has been done, in part because not enough is known about depression in this setting, and in part due the difficulty of carrying out psychiatric Intervention studies in this setting. To perform such research, the candidate will develop skills in the areas of psychiatric assessment of patients in medical settings, design of intervention trials, measurement of rehabilitation outcomes, and data management and biostatistical analysis. Proposed research consists of a longitudinal descriptive study characterizing late-life depression in medical rehabilitation settings, leading to a pilot intervention study assessing effects of depression treatment on rehabilitation outcomes. The proposed activities will take place in the NIMH-funded Intervention Research Center for Late Life Mood Disorders, directed by the candidate's sponsor, in the Department of Psychiatry at the University of Pittsburgh.

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Mentored Patient-Oriented Research Career Development Award (K23)
Project #
1K23MH064196-01
Application #
6359925
Study Section
Special Emphasis Panel (ZMH1-ITV-D (01))
Program Officer
Light, Enid
Project Start
2001-09-01
Project End
2006-08-31
Budget Start
2001-09-01
Budget End
2002-08-31
Support Year
1
Fiscal Year
2001
Total Cost
$165,913
Indirect Cost
Name
University of Pittsburgh
Department
Psychiatry
Type
Schools of Medicine
DUNS #
053785812
City
Pittsburgh
State
PA
Country
United States
Zip Code
15213
Lenze, Eric J; Skidmore, Elizabeth R; Begley, Amy E et al. (2012) Memantine for late-life depression and apathy after a disabling medical event: a 12-week, double-blind placebo-controlled pilot study. Int J Geriatr Psychiatry 27:974-80
Butters, Meryl A; Bhalla, Rishi K; Andreescu, Carmen et al. (2011) Changes in neuropsychological functioning following treatment for late-life generalised anxiety disorder. Br J Psychiatry 199:211-8
Talkowski, Jaime B; Lenze, Eric J; Munin, Michael C et al. (2009) Patient participation and physical activity during rehabilitation and future functional outcomes in patients after hip fracture. Arch Phys Med Rehabil 90:618-22
Lenze, Eric J; Munin, Michael C; Dew, Mary Amanda et al. (2009) Apathy after hip fracture: a potential target for intervention to improve functional outcomes. J Neuropsychiatry Clin Neurosci 21:271-8
Whyte, Ellen M; Lenze, Eric J; Butters, Meryl et al. (2008) An open-label pilot study of acetylcholinesterase inhibitors to promote functional recovery in elderly cognitively impaired stroke patients. Cerebrovasc Dis 26:317-21
Lenze, Eric J; Shardell, Michelle; Ferrell, Robert E et al. (2008) Association of serotonin-1A and 2A receptor promoter polymorphisms with depressive symptoms and functional recovery in elderly persons after hip fracture. J Affect Disord 111:61-6
Lenze, Eric J; Skidmore, Elizabeth R; Dew, Mary Amanda et al. (2007) Does depression, apathy or cognitive impairment reduce the benefit of inpatient rehabilitation facilities for elderly hip fracture patients? Gen Hosp Psychiatry 29:141-6
Lenze, Eric J; Munin, Michael C; Skidmore, Elizabeth R et al. (2007) Onset of depression in elderly persons after hip fracture: implications for prevention and early intervention of late-life depression. J Am Geriatr Soc 55:81-6
Mantella, Rose C; Butters, Meryl A; Dew, Mary Amanda et al. (2007) Cognitive impairment in late-life generalized anxiety disorder. Am J Geriatr Psychiatry 15:673-9
Koenig, Kris L; Whyte, Ellen M; Munin, Michael C et al. (2007) Stroke-related knowledge and health behaviors among poststroke patients in inpatient rehabilitation. Arch Phys Med Rehabil 88:1214-6

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