The major goal of this Mentored Patient-Oriented Research Career Development Award submission is to further the applicant's experience as a clinical efficacy researcher who has examined the impact of treatment in a controlled setting, to that of an investigator who examines how well clinical interventions work in actual clinical care settings, and for whom and at what costs.
Specific aims, met through a detailed educational plan and research projects, are to: (I) develop the skills to measure access to care, health outcomes, and the economic cost of illness; (2) expand expertise in evaluating and implementing non-pharmacologic treatments; (3) improve the ability to develop, administer, and manage research investigations conducted in publicly funded mental health settings; and (4) develop sophistication in the design, measurement, and statistical analytic methods required for effectiveness research. The educational plan consists of formal course-work; videotape training sessions; consultative sessions and off-site visits with key leaders in the field of effectiveness and schizophrenia research; and performance of Applied Educational Activities. The research plan includes a randomized controlled trial of the effectiveness of Compliance Therapy (CT) vs. nonspecific counseling in outpatients with schizophrenia treated in clinics of the Dallas public mental health system. The proposed project would build on earlier effectiveness work involving CT by extending the study of this intervention from inpatients in England to public mental health center outpatients in the United States. Finally, this application outlines work that would provide more information on treatment effectiveness of CT by extending outcome domains to include patient preference/satisfaction, functioning, quality of life, and economic costs.

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Mentored Patient-Oriented Research Career Development Award (K23)
Project #
5K23MH064930-02
Application #
6656847
Study Section
Special Emphasis Panel (ZMH1-SRV-C (01))
Program Officer
Oliver, Karen Anderson
Project Start
2002-09-06
Project End
2007-05-31
Budget Start
2003-06-01
Budget End
2004-05-31
Support Year
2
Fiscal Year
2003
Total Cost
$169,668
Indirect Cost
Name
University of Texas Sw Medical Center Dallas
Department
Psychiatry
Type
Schools of Medicine
DUNS #
800771545
City
Dallas
State
TX
Country
United States
Zip Code
75390
Nakonezny, Paul A; Byerly, Matthew J; Pradhan, Amit (2013) The effect of providing patient-specific electronically monitored antipsychotic medication adherence results on the treatment planning of prescribers of outpatients with schizophrenia. Psychiatry Res 208:9-14
Byerly, Matthew J; Nakonezny, Paul A; Rush, A John (2008) The Brief Adherence Rating Scale (BARS) validated against electronic monitoring in assessing the antipsychotic medication adherence of outpatients with schizophrenia and schizoaffective disorder. Schizophr Res 100:60-9
Byerly, Matthew J; Nakonezny, Paul A; Rush, A John (2008) Sexual functioning associated with quetiapine switch vs. risperidone continuation in outpatients with schizophrenia or schizoaffective disorder: a randomized double-blind pilot trial. Psychiatry Res 159:115-20
Nakonezny, Paul A; Byerly, Matthew J; Rush, A John (2008) Electronic monitoring of antipsychotic medication adherence in outpatients with schizophrenia or schizoaffective disorder: an empirical evaluation of its reliability and predictive validity. Psychiatry Res 157:259-63
Nakonezny, Paul A; Byerly, Matthew J; Rush, A John (2007) The relationship between serum prolactin level and sexual functioning among male outpatients with schizophrenia or schizoaffective disorder: a randomized double-blind trial of risperidone vs. quetiapine. J Sex Marital Ther 33:203-16
Byerly, Matthew J; Nakonezny, Paul A; Lescouflair, Emmeline (2007) Antipsychotic medication adherence in schizophrenia. Psychiatr Clin North Am 30:437-52
Byerly, Matthew J; Thompson, Ann; Carmody, Thomas et al. (2007) Validity of electronically monitored medication adherence and conventional adherence measures in schizophrenia. Psychiatr Serv 58:844-7
Byerly, Matthew J; Nakonezny, Paul A; Bettcher, Brianne Magouirk et al. (2006) Sexual dysfunction associated with second-generation antipsychotics in outpatients with schizophrenia or schizoaffective disorder: an empirical evaluation of olanzapine, risperidone, and quetiapine. Schizophr Res 86:244-50
Byerly, Matthew J; Nakonezny, Paul A; Fisher, Robert et al. (2006) An empirical evaluation of the Arizona sexual experience scale and a simple one-item screening test for assessing antipsychotic-related sexual dysfunction in outpatients with schizophrenia and schizoaffective disorder. Schizophr Res 81:311-6
Nakonezny, Paul A; Byerly, Matthew J (2006) Electronically monitored adherence in outpatients with schizophrenia or schizoaffective disorder: a comparison of first- vs. second-generation antipsychotics. Schizophr Res 82:107-14

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