This is an application for a Mentored Patient-Oriented Career Development Award (K23). The overall aim of the application is to provide the candidate with the research and educational experiences to become an independent investigator in the study of the effectiveness of anxiety treatment interventions with older adults in primary care settings. The research study proposed is designed to examine the outcomes of a cognitive behavioral guided self-care intervention with older adults diagnosed with generalized anxiety disorder and recruited from a primary care setting. The candidate has chosen a number of distinguished researchers to serve as mentors and consultants. The candidate's short-term goals are to strengthen her knowledge of and experience in the design, methodology, and logistics of late-life anxiety treatment studies; strengthen her knowledge and skills in the application of complex statistical methods in the analysis of results from effectiveness and treatment studies; refine an intervention manual for the treatment of anxiety disorders in older adults; and collect substantial pilot data in preparation for the submission of an R01 application to conduct a full late-life anxiety treatment effectiveness trial. The candidate's long-term goals are to develop expertise and become an independent investigator in the treatment of late-life anxiety; successfully prepare a funded R01 grant using the pilot data collected from the K Award; develop a program of research in the treatment of anxiety in older adults; and develop research skills and abilities sufficient to instruct and mentor junior faculty.

National Institute of Health (NIH)
National Institute of Mental Health (NIMH)
Mentored Patient-Oriented Research Career Development Award (K23)
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Study Section
Interventions Research Review Committee (ITV)
Program Officer
Chavez, Mark
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Wake Forest University Health Sciences
Schools of Medicine
United States
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Brenes, Gretchen A; Miller, Michael E; Williamson, Jeff D et al. (2012) A randomized controlled trial of telephone-delivered cognitive-behavioral therapy for late-life anxiety disorders. Am J Geriatr Psychiatry 20:707-16
Brenes, Gretchen A; Ingram, Cobi W; Danhauer, Suzanne C (2012) Telephone-delivered psychotherapy for late-life anxiety. Psychol Serv 9:219-20
Brenes, Gretchen A; Ingram, Cobi W; Danhauer, Suzanne C (2011) Benefits and Challenges of Conducting Psychotherapy by Telephone. Prof Psychol Res Pr 42:543-549
Brenes, Gretchen A; McCall, W Vaughn; Williamson, Jeff D et al. (2010) Feasibility and Acceptability of Bibliotherapy and Telephone Sessions for the Treatment of Late-life Anxiety Disorders. Clin Gerontol 33:62-68
Brenes, Gretchen A; Miller, Michael E; Stanley, Melinda A et al. (2009) Insomnia in older adults with generalized anxiety disorder. Am J Geriatr Psychiatry 17:465-72
Brenes, G A; Penninx, B W J H; Judd, P H et al. (2008) Anxiety, depression and disability across the lifespan. Aging Ment Health 12:158-63
Brenes, Gretchen A; Knudson, Mark; McCall, W Vaughn et al. (2008) Age and racial differences in the presentation and treatment of Generalized Anxiety Disorder in primary care. J Anxiety Disord 22:1128-36
Brenes, Gretchen A; Kritchevsky, Stephen B; Mehta, Kala M et al. (2007) Scared to death: results from the Health, Aging, and Body Composition study. Am J Geriatr Psychiatry 15:262-5
Brenes, G A; Williamson, J D; Messier, S P et al. (2007) Treatment of minor depression in older adults: a pilot study comparing sertraline and exercise. Aging Ment Health 11:61-8
Brenes, G A (2006) Age differences in the presentation of anxiety. Aging Ment Health 10:298-302

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