The goal of this Mentored Patient-Oriented Research Career Development Award (K23) is to allow me to become an independent, transdisciplinary researcher examining sex differences in stress responses and depression over puberty. I am a new Assistant Professor at the Brown University Center for Behavioral and Preventive Medicine with previous research focusing on sex differences in stress responses and depression in adults. Training from this K23 proposal will allow me to re-focus on adolescents and to develop a program of research examining: a) How do HPA responses to stress change across puberty in boys and girls? and b) Do changes in HPA responses to stress over puberty influence the emergence of sex differences in depression? My Career Development Plan includes training in social and biological influences on adolescent development, nosology and measurement of adolescent depression, statistical methods and ethics. My research goals include carrying out the K23 study, building a base of publications in adolescent stress responses and depression, and the submission of an R01. Guiding my training and research will be four transdisciplinary Mentors: Raymond Niaura, Ph.D. (sex differences in stress responses); Ronald Seifer, Ph.D. (high-risk children, statistics, ethics); Ronald Dahl, M.D. (puberty, depression, brain stress systems) and Adrian Angold, MRCPsych (sex differences in depression, nosology, statistics). The Research Plan involves a cross-sectional investigation of sex differences in stress responses across stages of puberty in adolescents at risk for depression (offspring of depressed mothers). I hypothesize that in the early stages of puberty there will be no sex differences in HPA responses to interpersonal and instrumental stress. In advanced puberty, however, paralleling the emergence of sex differences in depression, girls will show greater responses to interpersonal compared to achievement stress, but boys will show greater responses to achievement compared to interpersonal stress. The K23 study will represent pilot data for a longitudinal study of stress responses and depression over puberty (R01 submission). This work has implications for targeted intervention and prevention efforts to diminish sex differences in adolescent depression. It should also elucidate basic interactions between the gonadal and stress axes over puberty.

National Institute of Health (NIH)
National Institute of Mental Health (NIMH)
Mentored Patient-Oriented Research Career Development Award (K23)
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Biobehavioral and Behavioral Processes 3 (BBBP)
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Boyce, Cheryl A
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Miriam Hospital
United States
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Allwood, Maureen A; Gaffey, Allison E; Vergara-Lopez, Chrystal et al. (2017) Stress through the mind of the beholder: preliminary differences in child and maternal perceptions of child stress in relation to child cortisol and cardiovascular activity. Stress 20:341-349
Laurent, Heidemarie K; Stroud, Laura R; Brush, Bridget et al. (2015) Secretory IgA reactivity to social threat in youth: Relations with HPA, ANS, and behavior. Psychoneuroendocrinology 59:81-90
Allwood, Maureen A; Handwerger, Kathryn; Kivlighan, Katie T et al. (2011) Direct and moderating links of salivary alpha-amylase and cortisol stress-reactivity to youth behavioral and emotional adjustment. Biol Psychol 88:57-64
Salisbury, Amy L; Wisner, Katherine L; Pearlstein, Teri et al. (2011) Newborn neurobehavioral patterns are differentially related to prenatal maternal major depressive disorder and serotonin reuptake inhibitor treatment. Depress Anxiety 28:1008-19
Stroud, Laura R; Papandonatos, George D; Williamson, Douglas E et al. (2011) Sex differences in cortisol response to corticotropin releasing hormone challenge over puberty: Pittsburgh Pediatric Neurobehavioral Studies. Psychoneuroendocrinology 36:1226-38
Stroud, Laura R; Paster, Rachel L; Papandonatos, George D et al. (2009) Maternal smoking during pregnancy and newborn neurobehavior: effects at 10 to 27 days. J Pediatr 154:10-6
Stroud, Laura R; Foster, Elizabeth; Papandonatos, George D et al. (2009) Stress response and the adolescent transition: performance versus peer rejection stressors. Dev Psychopathol 21:47-68
Forcier, Kathleen; Stroud, Laura R; Papandonatos, George D et al. (2006) Links between physical fitness and cardiovascular reactivity and recovery to psychological stressors: A meta-analysis. Health Psychol 25:723-39
Koenen, Karestan C; Hitsman, Brian; Lyons, Michael J et al. (2006) Posttraumatic stress disorder and late-onset smoking in the Vietnam era twin registry. J Consult Clin Psychol 74:186-90
Capaldi Ii, Vincent F; Handwerger, Kathryn; Richardson, Elizabeth et al. (2005) Associations between sleep and cortisol responses to stress in children and adolescents: a pilot study. Behav Sleep Med 3:177-92

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