This revised application for a Mentored Patient-Oriented Research Career Development Award (K23) presents a plan for Dr. Cheryl Corcoran to pursue training and research in the prospective assessment of the schizophrenia prodrome, specifically risk factors, intervening variables and markers associated with the onset of psychosis. The goals of the training and research plan are integrated around the hypothesis that the neural diathesis of schizophrenia liability involves a vulnerability to develop psychosis in the context of psychosocial stress. Dr. Corcoran currently has experience in studying 1) the schizophrenia prodrome and 2) stress exposure and its correlates in schizophrenia. Under the sponsorship of Dr. Malaspina, and drawing upon resources at both NYSPI/Columbia and Hillside Hospital, Dr. Corcoran's training plan combines formal coursework and direct supervision with clinical research experience and training. Dr. Corcoran has established a prodromal research clinic at NYSPI, entitled the """"""""Center of Prevention and Evaluation"""""""" (COPE). The training plan involves 1) clinical methodologies in the assessment of stress and the HPA axis in schizophrenia (Malaspina); 2) increased expertise in prodromal research and neuropsychology (Cornblatt); 3) data analysis in longitudinal studies (Begg) and 4) adolescent cognitive and social development (Kestenbuam). The research plan is a prospective cohort study of prodromal patients that employs clinical methodologies that probe HPA axis function, prodromal symptoms, and psychosocial stress exposure. The hypotheses are that baseline stress-reactivity (stress reactive cortisol and impaired tolerance to normal stress) and intervening life events will increase risk for psychosis in prodromal patients. Important covariates are also evaluated, including cognition, early trauma, and medication and substance use. This study will provide the applicant with the knowledge and research experience necessary to apply for an R01 to further evaluate risk factors, mediators and markers of psychosis onset in prodromal patients.

National Institute of Health (NIH)
National Institute of Mental Health (NIMH)
Mentored Patient-Oriented Research Career Development Award (K23)
Project #
Application #
Study Section
Neural Basis of Psychopathology, Addictions and Sleep Disorders Study Section (NPAS)
Program Officer
Boyce, Cheryl A
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
Columbia University (N.Y.)
Schools of Medicine
New York
United States
Zip Code
Crump, Francesca M; Arndt, Leigh; Grivel, Margaux et al. (2018) Attenuated first-rank symptoms and conversion to psychosis in a clinical high-risk cohort. Early Interv Psychiatry 12:1213-1216
Brucato, Gary; Appelbaum, Paul S; Masucci, Michael D et al. (2018) Prevalence and phenomenology of violent ideation and behavior among 200 young people at clinical high-risk for psychosis: an emerging model of violence and psychotic illness. Neuropsychopharmacology :
Masucci, Michael D; Lister, Amanda; Corcoran, Cheryl M et al. (2018) Motor Dysfunction as a Risk Factor for Conversion to Psychosis Independent of Medication Use in a Psychosis-Risk Cohort. J Nerv Ment Dis 206:356-361
Poe, Sarah-Lucy; Brucato, Gary; Bruno, Nicolina et al. (2017) Sleep disturbances in individuals at clinical high risk for psychosis. Psychiatry Res 249:240-243
Brucato, G; Masucci, M D; Arndt, L Y et al. (2017) Baseline demographics, clinical features and predictors of conversion among 200 individuals in a longitudinal prospective psychosis-risk cohort. Psychol Med 47:1923-1935
Ruby, Eugene; Rothman, Karen; Corcoran, Cheryl et al. (2017) Influence of early trauma on features of schizophrenia. Early Interv Psychiatry 11:322-333
Fusar-Poli, Paolo; Cappucciati, Marco; Borgwardt, Stefan et al. (2016) Heterogeneity of Psychosis Risk Within Individuals at Clinical High Risk: A Meta-analytical Stratification. JAMA Psychiatry 73:113-20
Gill, Kelly E; Cressman, Victoria; Poe, Sarah Lucy et al. (2016) Social inference in individuals at clinical high risk for psychosis. Early Interv Psychiatry 10:77-80
Gill, Kelly E; Poe, Lucy; Azimov, Neyra et al. (2015) Reasons for cannabis use among youths at ultra high risk for psychosis. Early Interv Psychiatry 9:207-10
Bedi, Gillinder; Carrillo, Facundo; Cecchi, Guillermo A et al. (2015) Automated analysis of free speech predicts psychosis onset in high-risk youths. NPJ Schizophr 1:15030

Showing the most recent 10 out of 50 publications