(provided by candidate): This is a resubmission of an application for a Mentored Patient-Oriented Research Career Development Award (K23). The candidate is a geriatric psychiatrist and post-doctoral research fellow at the University of Pittsburgh. She proposes to become an expert in clinical mental-health prevention research. This proposal focuses on post-stroke major depression (PSMD) as this illness is a model of geriatric depression and is an illness ready for preventive intervention research. To develop the skills needed to conduct clinical mental-health prevention research, the candidate will learn from the related fields of epidemiology, public health prevention research, and traditional mental-health pharmacologic intervention research. She will gain the skills needed (1) to design and conduct prevention studies, and (2) to select at-risk populations that would benefit from preventive interventions through the identification and modeling of risk factors. In addition, the candidate will develop the skills needed to assess psychiatric and functional outcomes in subjects with neurological illness. The candidate will also learn about biostatistical analysis pertinent to prevention trials and the ethical issues involved in clinical research. Funding of this award will provide time and resources necessary for the candidate to develop into an independent investigator capable of conducting psychiatric prevention and intervention trials in impaired elderly depressed patients. Studies of stroke survivors indicate that Major Depression is common after stroke and is associated with poorer rehabilitation outcomes, increased disability, and increased mortality. While the response rate in treatment trials of PSMD is typically 65%, it is unclear whether successful treatment of PSMD translates into improved rehabilitation outcomes. Therefore, preventing the onset of PSMD may be a more beneficial approach in terms of both mental and physical health. The proposed research is a pilot double-blind placebo controlled trial of citalopram in the prevention of PSMD in stroke survivors at high-risk for developing PSMD. The proposed activities will take place at the University of Pittsburgh under the auspices of the NIMH-funded Intervention Research Center for Late Life Mood Disorders, directed by the candidate's sponsor.

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Mentored Patient-Oriented Research Career Development Award (K23)
Project #
5K23MH067710-04
Application #
7156907
Study Section
Interventions Research Review Committee (ITV)
Program Officer
Chavez, Mark
Project Start
2004-01-01
Project End
2008-12-31
Budget Start
2007-01-01
Budget End
2007-12-31
Support Year
4
Fiscal Year
2007
Total Cost
$172,778
Indirect Cost
Name
University of Pittsburgh
Department
Psychiatry
Type
Schools of Medicine
DUNS #
004514360
City
Pittsburgh
State
PA
Country
United States
Zip Code
15213
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Davies, Simon J C; Mulsant, Benoit H; Flint, Alastair J et al. (2016) SSRI-antipsychotic combination in psychotic depression: sertraline pharmacokinetics in the presence of olanzapine, a brief report from the STOP-PD study. Hum Psychopharmacol 31:252-5
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Østergaard, Søren D; Meyers, Barnett S; Flint, Alastair J et al. (2014) Measuring treatment response in psychotic depression: the Psychotic Depression Assessment Scale (PDAS) takes both depressive and psychotic symptoms into account. J Affect Disord 160:68-73
Østergaard, S D; Meyers, B S; Flint, A J et al. (2014) Measuring psychotic depression. Acta Psychiatr Scand 129:211-20
Deligiannidis, Kristina M; Rothschild, Anthony J; Barton, Bruce A et al. (2013) A gender analysis of the study of pharmacotherapy of psychotic depression (STOP-PD): gender and age as predictors of response and treatment-associated changes in body mass index and metabolic measures. J Clin Psychiatry 74:1003-9
Lenze, Eric J; Skidmore, Elizabeth R; Begley, Amy E et al. (2012) Memantine for late-life depression and apathy after a disabling medical event: a 12-week, double-blind placebo-controlled pilot study. Int J Geriatr Psychiatry 27:974-80
Skidmore, Elizabeth R; Whyte, Ellen M; Holm, Margo B et al. (2010) Cognitive and affective predictors of rehabilitation participation after stroke. Arch Phys Med Rehabil 91:203-7
Martire, Lynn M; Schulz, Richard; Reynolds 3rd, Charles F et al. (2010) Treatment of late-life depression alleviates caregiver burden. J Am Geriatr Soc 58:23-9

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