(provided by candidate): This grant application on behalf of Daniel Weintraub, MD, Assistant Professor of Psychiatry at the University of Pennsylvania, is for the Mentored Patient-Oriented Research Career Development Award,(K23). The focus of this award is to enable Dr. Weintraub (PI) to acquire the academic and research expertise to achieve his career goal of becoming an independent researcher in the assessment and treatment of the psychiatric complications of Parkinson's disease (PD), an area in which there is an urgent need for clinical research due to a lack of consensus over phenomenology and the lack of empirical evidence to support current treatment practice. The research plan for this award will in part involve conducting a depression screening and assessment process in two PD specialty care settings in order to determine demographic, psychiatric, neurologic, and cognitive correlates of depression and to propose modified criteria for affective disorders in PD. In conjunction with this, the PI will conduct an open-label antidepressant study using escitalopram to determine response rates under treatment as a function of different diagnostic criteria and to identify moderators of response under treatment. The impact of antidepressant treatment on comorbid psychiatric and cognitive symptoms, motor symptoms, quality of life, and caregiver burden will also be probed. Identification of modifiers of treatment response will help inform future studies and clinical decision-making. The career development plan will revolve around the acquisition of skills related to Dr. Weintraub becoming a research geriatric- and neuro-psychiatrist with expertise in Parkinson's disease and proficient in conducting intervention research in this area. The specific skill areas to be developed during the course of the proposed award relate to: (1) intervention research and biostatistics; (2) clinical neuroscience; and (3) the neurology of Parkinson's disease (PD). Methods of career development include: (1) the proposed research study; (2) the mentorship of Drs. Ira Katz and Matthew Stern; (3) consultation with experts in assessment and treatment of geriatric depression and neuropsychiatric disease; (4) formal coursework in clinical trials research, biostatistics, clinical neuroscience, and neurology; (5) training in the assessment and treatment of Parkinson's disease (6) attendance at scientific meetings; and (7) mentored data analysis and manuscript preparation.

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Mentored Patient-Oriented Research Career Development Award (K23)
Project #
5K23MH067894-04
Application #
7152842
Study Section
Interventions Research Review Committee (ITV)
Program Officer
Chavez, Mark
Project Start
2003-12-01
Project End
2008-11-30
Budget Start
2006-12-01
Budget End
2007-11-30
Support Year
4
Fiscal Year
2007
Total Cost
$180,279
Indirect Cost
Name
University of Pennsylvania
Department
Psychiatry
Type
Schools of Medicine
DUNS #
042250712
City
Philadelphia
State
PA
Country
United States
Zip Code
19104
Stankovic, Iva; Krismer, Florian; Jesic, Aleksandar et al. (2014) Cognitive impairment in multiple system atrophy: a position statement by the Neuropsychology Task Force of the MDS Multiple System Atrophy (MODIMSA) study group. Mov Disord 29:857-67
Weintraub, Daniel; Nirenberg, Melissa J (2013) Impulse control and related disorders in Parkinson's disease. Neurodegener Dis 11:63-71
Litvan, Irene; Goldman, Jennifer G; Tröster, Alexander I et al. (2012) Diagnostic criteria for mild cognitive impairment in Parkinson's disease: Movement Disorder Society Task Force guidelines. Mov Disord 27:349-56
Lee, Angela H; Weintraub, Daniel (2012) Psychosis in Parkinson's disease without dementia: common and comorbid with other non-motor symptoms. Mov Disord 27:858-63
Manning, Kevin J; Clarke, Christina; Lorry, Alan et al. (2012) Medication management and neuropsychological performance in Parkinson's disease. Clin Neuropsychol 26:45-58
Weintraub, Daniel; Mamikonyan, Eugenia; Papay, Kimberly et al. (2012) Questionnaire for Impulsive-Compulsive Disorders in Parkinson's Disease-Rating Scale. Mov Disord 27:242-7
Weintraub, Daniel; Chen, Peijun; Ignacio, Rosalinda V et al. (2011) Patterns and trends in antipsychotic prescribing for Parkinson disease psychosis. Arch Neurol 68:899-904
Morley, James F; Weintraub, Daniel; Mamikonyan, Eugenia et al. (2011) Olfactory dysfunction is associated with neuropsychiatric manifestations in Parkinson's disease. Mov Disord 26:2051-7
Weintraub, Daniel; Burn, David J (2011) Parkinson's disease: the quintessential neuropsychiatric disorder. Mov Disord 26:1022-31
Aarsland, D; Bronnick, K; Williams-Gray, C et al. (2010) Mild cognitive impairment in Parkinson disease: a multicenter pooled analysis. Neurology 75:1062-9

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