This K23 application will prepare the candidate for an independent research career in the clinical epidemiology of late-life mental disorders. The focus of the research project is to determine the degree to which early and mid-life depressive spectrum disorder increases risk of developing cognitive deficits in later life. Late-life depression has been associated with subsequent development of cognitive deficits in late life,but no previous study has examined the association between early and mid-life depression and later life cognitive deficits. The proposed study provides an unusual, time-sensitive opportunity to test this hypothesis by taking advantage of the recently funded fourth wave of the Baltimore Epidemiologic Catchment Area (ECA) study. Using a retrospective cohort design, the investigator proposes to sample people with depression before age 50 as assessed in previous waves of the Baltimore ECA studies, and examine their neuropsychological outcomes 10 to 23 years later.
The specific aims of the proposal are: 1) to determine whether early and mid-life depressive spectrum disorder (before age 50) increases risk of developing Mild Cognitive Impairment or dementia in later life (after age 60), 2) to investigate the longitudinal association between early and mid-life depressive spectrum disorder and late life cognitive deficits in specific neuropsychological domains (i.e. executive function and memory), and 3) to estimate what extent duration, number of episodes, and severity of early and mid-life depressive spectrum disorder predict cognitive impairment in late life. This study will serve as a vehicle for the candidate to obtain invaluable experience in the design and fieldwork of an epidemiologic study of the aging population. To complement his practical research training, the candidate will concurrently enroll in formal courses in Epidemiology and Biostatistics of Aging and fulfill the requirements for a Master's degree. He will participate in seminars in the post-doctoral program in neuropsychology to develop advanced knowledge in use and interpretation of neuropsychological instruments. A panel of mentors and consultants (Drs. Constantine Lyketsos, William Eaton, Jason Brandt, George Rebok, Kung-Yee Liang, George Alexopoulos, and Anand Kumar) will guide his research and training. This award will provide groundwork for his long term goal of becoming an expert in clinical epidemiology of late life mental disorders.

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Mentored Patient-Oriented Research Career Development Award (K23)
Project #
5K23MH068793-02
Application #
6867440
Study Section
Behavioral Genetics and Epidemiology Study Section (BGES)
Program Officer
Chavez, Mark
Project Start
2004-04-01
Project End
2009-03-31
Budget Start
2005-04-01
Budget End
2006-03-31
Support Year
2
Fiscal Year
2005
Total Cost
$162,852
Indirect Cost
Name
Johns Hopkins University
Department
Other Health Professions
Type
Schools of Public Health
DUNS #
001910777
City
Baltimore
State
MD
Country
United States
Zip Code
21218
Lee, Hochang Benjamin; Offidani, Emanuela; Ziegelstein, Roy C et al. (2014) Five-factor model personality traits as predictors of incident coronary heart disease in the community: a 10.5-year cohort study based on the Baltimore epidemiologic catchment area follow-up study. Psychosomatics 55:352-361
Mezuk, Briana; Golden, Sherita Hill; Eaton, William W et al. (2012) Depression and body composition among older adults. Aging Ment Health 16:167-72
Lee, Hochang B; Richardson, Amanda K; Black, Betty S et al. (2012) Race and cognitive decline among community-dwelling elders with mild cognitive impairment: findings from the Memory and Medical Care Study. Aging Ment Health 16:372-7
Ramsey, Christine M; Leoutsakos, Jeannie-Marie; Mayer, Lawrence S et al. (2010) History of manic and hypomanic episodes and risk of incident cardiovascular disease: 11.5 year follow-up from the Baltimore Epidemiologic Catchment Area Study. J Affect Disord 125:35-41
Lee, Hochang Benjamin; Bienvenu, O Joseph; Cho, Seong-Jin et al. (2010) Personality disorders and traits as predictors of incident cardiovascular disease: findings from the 23-year follow-up of the Baltimore ECA study. Psychosomatics 51:289-96
Kalaydjian, A; Bienvenu, O J; Hening, W A et al. (2009) Restless Legs Syndrome and the five-factor model of personality: results from a community sample. Sleep Med 10:672-5
Mezuk, Briana; Eaton, William W; Golden, Sherita Hill et al. (2008) Depression, antidepressants, and bone mineral density in a population-based cohort. J Gerontol A Biol Sci Med Sci 63:1410-5
Lee, Hochang B; DeLoatch, Candyce J; Cho, SeongJin et al. (2008) Detection and management of pre-existing cognitive impairment and associated behavioral symptoms in the Intensive Care Unit. Crit Care Clin 24:723-36, viii
Lee, Hochang B; Hening, Wayne A; Allen, Richard P et al. (2008) Restless legs syndrome is associated with DSM-IV major depressive disorder and panic disorder in the community. J Neuropsychiatry Clin Neurosci 20:101-5
Lee, Hochang B; Hening, Wayne A; Allen, Richard P et al. (2006) Race and restless legs syndrome symptoms in an adult community sample in east Baltimore. Sleep Med 7:642-5

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