This application for an NIMH Mentored Patient-Oriented Career Development Award (K23), titled """"""""Adherence to HCV Treatment in HCV and HCV/HIV Patients,"""""""" seeks to develop the Principal Investigator (PI), a clinical psychologist, into an independent investigator performing research with nonadherent medically ill patients with comorbid psychiatric and substance use disorders. The short-term career goals of the PI include obtaining (1) knowledge of the diagnosis and treatment of HCV and HIV infections, (2) knowledge of the measurement of adherence and of the biological consequences of non-adherence, (3) training in substance abuse-related issues and neurocognitive aspects of HIV/HCV and substance abuse (4) training in research methodology, statistics, grant writing (5) training in public health and policy aspects of research on (former) injection drug users, (6) training in the conduct of ethical research, (7) training in the administration of structured psychiatric interview schedules. The long-term goals of the PI include conducting research on the impact of comorbid medical and psychiatric conditions on adherence to medical treatment, particularly with HCV and HCV/HIV patients. The research proposed is a prospective cohort study in which 100 HCV and 100 HCV/HIV patients will be enrolled just prior to initiating HCV therapy with pegylated IFN-alfa and ribavirin (PEG-IFN/RBV). Treatment with PEG-IFN/RBV is associated with numerous hematologic, physical, and neuropsychiatric side effects, which lead to high rates of early treatment discontinuation. The 200 recruited patients will be followed for the first 24 weeks of treatment to determine whether depression, neurocognitive functioning, substance abuse and treatment self-efficacy are associated with early treatment discontinuation in these two groups of patients and whether the two groups differ in rates of early treatment discontinuation. The findings of this study will have important implications for the development of interventions to support and assist HCV and HCV/HIV patients in completing their course of PEG-IFN/RBV treatment.

National Institute of Health (NIH)
National Institute of Mental Health (NIMH)
Mentored Patient-Oriented Research Career Development Award (K23)
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Study Section
Behavioral and Social Consequences of HIV/AIDS Study Section (BSCH)
Program Officer
Stirratt, Michael J
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Mount Sinai School of Medicine
Schools of Medicine
New York
United States
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Weiss, Jeffrey J; Prieto, Sarah; Bräu, Norbert et al. (2018) Multimethod assessment of baseline depression and relationship to hepatitis C treatment discontinuation. Int J Psychiatry Med 53:256-272
Miller, Theodore R; Weiss, Jeffrey J; Bräu, Norbert et al. (2017) Greater decline in memory and global neurocognitive function in HIV/hepatitis C co-infected than in hepatitis C mono-infected patients treated with pegylated interferon and ribavirin. J Neurovirol 23:260-272
Pizzirusso, Maria; Lin, Jenny; Head, Cory et al. (2014) Impact of hepatitis C treatment initiation on adherence to concomitant medications. J Assoc Nurses AIDS Care 25:23-31
Weiss, Jeffrey J; Alcorn, Marlene C; Rabkin, Judith G et al. (2012) The critical role of medication adherence in the success of boceprevir and telaprevir in clinical practice. J Hepatol 56:503-4
Weiss, Jeffrey J; Osorio, Georgina; Ryan, Elizabeth et al. (2010) Prevalence and patient awareness of medical comorbidities in an urban AIDS clinic. AIDS Patient Care STDS 24:39-48
Weiss, Jeffrey J; Morgello, Susan (2009) Psychiatric management of HIV/HCV-coinfected patients beginning treatment for hepatitis C virus infection: survey of provider practices. Gen Hosp Psychiatry 31:531-7
Weiss, J J; Bräu, N; Stivala, A et al. (2009) Review article: adherence to medication for chronic hepatitis C - building on the model of human immunodeficiency virus antiretroviral adherence research. Aliment Pharmacol Ther 30:14-27
Weiss, J J; Bhatti, L; Dieterich, D T et al. (2008) Hepatitis C patients'self-reported adherence to treatment with pegylated interferon and ribavirin. Aliment Pharmacol Ther 28:289-93
Weiss, J J; Bhatti, L; Dieterich, D T et al. (2008) Hepatitis C patients'self-reported adherence to pegylated interferon and ribavirin. Aliment Pharmacol Ther :
Weiss, Jeffrey J; Gorman, Jack M (2006) Psychiatric behavioral aspects of comanagement of hepatitis C virus and HIV. Curr HIV/AIDS Rep 3:176-81