Career Development Plan: I am requesting five years of funding through a Mentored Patient-Oriented Research Career Development Award in AIDS Research (PA-03-086) in order to develop as an independent researcher investigating neuropsychiatric and neurophysiologic features of HIV/HCV coinfection. My overall goals are 1) to learn about HIV/HCV coinfection and its impact on the brain and 2) to implement a research project investigating cognitive, psychiatric, and neurophysiologic features of HIV/HCV coinfection. My ultimate career goal is to become an independent investigator of the neuropsychiatric features of comorbidities in neuroAIDS. Career Development Plan: A comprehensive program is proposed that includes a didactic curriculum, tutorials in magnetic resonance spectroscopy imaging (MRSI), neurobiology of HIV, HIV/HCV coinfection, and neuropsychiatric research methods. Background of Proposed Research Project: HIV/HCV coinfection is an emerging, significant comorbidity in neuroAIDS. To date, the neurobehavioral consequences of HIV/HCV coinfection have not been fully characterized although each virus has been shown to independently cause neuropsychiatric disturbance. Research Project Aims: To determine whether a differential effect of HCV viremia can be detected in brain via neurometabolites and in behavior via neuropsychologic deficits among HIV/HCV coinfected, HCV-only, and HIV-only monoinfected patients. Methods: One hundred HIV/HCV coinfected patients with and without HCV viremia as well as 50 HIV-only and 50 HCV-only patients will receive a MRSI, a psychiatric interview, and a neuropsychologic assessment. The study will test the hypothesis that HCV viremia is associated with increased choline, increased myo-inositol, and increased GIx as well as executive functioning deficits. Significance: This study will identify neuropsychiatric and neurophysiologic features of HCV viremia in HIV/HCV coinfection and will serve as a template for neuropsychiatric research of comorbidities in neuroAIDS.

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Mentored Patient-Oriented Research Career Development Award (K23)
Project #
1K23MH071181-01A1
Application #
6842408
Study Section
NeuroAIDS and other End-Organ Diseases Study Section (NAED)
Program Officer
Joseph, Jeymohan
Project Start
2004-08-24
Project End
2009-07-31
Budget Start
2004-08-24
Budget End
2005-07-31
Support Year
1
Fiscal Year
2004
Total Cost
$160,655
Indirect Cost
Name
Mount Sinai School of Medicine
Department
Psychiatry
Type
Schools of Medicine
DUNS #
078861598
City
New York
State
NY
Country
United States
Zip Code
10029
Weiss, Jeffrey J; Osorio, Georgina; Ryan, Elizabeth et al. (2010) Prevalence and patient awareness of medical comorbidities in an urban AIDS clinic. AIDS Patient Care STDS 24:39-48
Murray, Jacinta; Fishman, Sarah L; Ryan, Elizabeth et al. (2008) Clinicopathologic correlates of hepatitis C virus in brain: a pilot study. J Neurovirol 14:17-27