The proposed Mentored Patient-Oriented Research Career Development Award (K23) is a five-year plan to develop the candidate into an independent depression prevention intervention researcher. The candidate outlines a application integrating formal coursework, consultation with established depression and prevention investigators, and an independent research program that will enable the candidate to: (1) develop comprehensive knowledge of prevention science, particularly prevention interventions; (2) increase her understanding of adolescent depression and the risks associated with developing a depressive disorder; (3) acquire training in conducting randomized prevention trials for children and adolescents; and (4) enhance skills related to the analysis of data from prevention trials and issues of mediation and moderation. The candidate proposes to extend previous work in depression prevention by studying Interpersonal Psychotherapy-Adolescent Skills Training (IPT-AST), her modification of Interpersonal Psychotherapy for Depressed Adolescents (IPT-A). IPT-AST is a school-based group preventive intervention for adolescents with elevated depressive symptoms focusing on psychoeducation and interpersonal skill-building. The core project will be a controlled clinical trial comparing IPT-AST, IPT-AST plus 3 additional parent-adolescent sessions (enhanced IPT-AST), and usual care in adolescents with subthreshold depression. Immediate and long-term assessments of depression symptoms, depressive disorders, and interpersonal functioning are proposed to determine whether: (1) IPT-AST and enhanced IPT-AST are associated with relief of depressive symptoms and prevention of depressive disorders as compared to usual care; (2) the parent-adolescent sessions in enhanced IPT-AST have an additional impact on adolescents' depressive symptoms and functioning; (3) there is preliminary evidence that interpersonal functioning mediates, and age and gender moderate, the effects of the intervention. The ultimate goal of the proposed program is to prepare the candidate to submit a successful application to test the efficacy of the optimal IPT-AST intervention in a larger, randomized controlled trial. ? ? ?

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Mentored Patient-Oriented Research Career Development Award (K23)
Project #
5K23MH071320-02
Application #
6925335
Study Section
Interventions Research Review Committee (ITV)
Program Officer
Vitiello, Benedetto
Project Start
2004-07-20
Project End
2009-06-30
Budget Start
2005-07-01
Budget End
2006-06-30
Support Year
2
Fiscal Year
2005
Total Cost
$176,796
Indirect Cost
Name
Columbia University (N.Y.)
Department
Psychiatry
Type
Schools of Medicine
DUNS #
621889815
City
New York
State
NY
Country
United States
Zip Code
10032
Siddique, Juned; de Chavez, Peter J; Howe, George et al. (2018) Limitations in Using Multiple Imputation to Harmonize Individual Participant Data for Meta-Analysis. Prev Sci 19:95-108
Brown, C Hendricks; Brincks, Ahnalee; Huang, Shi et al. (2018) Two-Year Impact of Prevention Programs on Adolescent Depression: an Integrative Data Analysis Approach. Prev Sci 19:74-94
Brincks, Ahnalee; Montag, Samantha; Howe, George W et al. (2018) Addressing Methodologic Challenges and Minimizing Threats to Validity in Synthesizing Findings from Individual-Level Data Across Longitudinal Randomized Trials. Prev Sci 19:60-73
Young, Jami F; Kranzler, Amy; Gallop, Robert et al. (2012) Interpersonal Psychotherapy-Adolescent Skills Training: Effects on School and Social Functioning. School Ment Health 4:254-264
Young, Jami F; Makover, Heather B; Cohen, Joseph R et al. (2012) Interpersonal psychotherapy-adolescent skills training: anxiety outcomes and impact of comorbidity. J Clin Child Adolesc Psychol 41:640-53
Young, Jami F; Mufson, Laura; Gallop, Robert (2010) Preventing depression: a randomized trial of interpersonal psychotherapy-adolescent skills training. Depress Anxiety 27:426-33
Young, Jami F; Gallop, Robert; Mufson, Laura (2009) Mother-child conflict and its moderating effects on depression outcomes in a preventive intervention for adolescent depression. J Clin Child Adolesc Psychol 38:696-704
Horowitz, Jason L; Garber, Judy; Ciesla, Jeffrey A et al. (2007) Prevention of depressive symptoms in adolescents: a randomized trial of cognitive-behavioral and interpersonal prevention programs. J Consult Clin Psychol 75:693-706