Cognitive deficits are a persistent and debilitating aspect of schizophrenia. Developing pharmacological treatments to reduce these deficits is becoming a primary focus of drug development and clinical trials. The clinical neuropsychological tests most widely used to test for cognitive enhancement efficacy were not designed to track cognitive change over time or be sensitive to behavioral effects of drugs targeting specific neurotransmitter systems. The field needs clinical investigators with the skills to 1) develop and evaluate new tools, with potential for increased sensitivity and efficiency in monitoring cognitive change, which are based on contemporary cognitive neuroscience and animal models of behavioral pharmacology, and 2) apply these tools in fMRI studies to directly assess drug effects on brain systems and provide a more efficient evaluation of drug effects in this population. This line of work offers excellent promise for facilitating the emergence of effective new pharmacological treatments targeting cognitive deficits in schizophrenia. The primary objectives of the proposed career development activities are to enhance the candidate's expertise in the areas of animal models of working memory, cognitive neuroscience, behavioral pharmacology, and functional brain imaging. This will prepare the candidate to lead an independent program of research evaluating cognitive enhancement medications for schizophrenia. Research activities will focus on conducting the behavioral and functional imaging studies to characterize serial order processing paradigms from cognitive neuroscience. This foundation of empirical data is needed to justify research strategies and neurocognitive tools prior to moving forward in evaluating treatment effects on cognition in clinical trial settings. ? ?

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Mentored Patient-Oriented Research Career Development Award (K23)
Project #
5K23MH072767-03
Application #
7342821
Study Section
Special Emphasis Panel (ZRG1-BDCN-E (02))
Program Officer
Chavez, Mark
Project Start
2005-03-01
Project End
2011-02-28
Budget Start
2008-03-01
Budget End
2009-02-28
Support Year
3
Fiscal Year
2008
Total Cost
$159,438
Indirect Cost
Name
University of Illinois at Chicago
Department
Psychiatry
Type
Schools of Medicine
DUNS #
098987217
City
Chicago
State
IL
Country
United States
Zip Code
60612
Hochberger, W C; Combs, T; Reilly, J L et al. (2018) Deviation from expected cognitive ability across psychotic disorders. Schizophr Res 192:300-307
Eum, Seenae; Hill, S Kristian; Rubin, Leah H et al. (2017) Cognitive burden of anticholinergic medications in psychotic disorders. Schizophr Res 190:129-135
Nanda, Pranav; Tandon, Neeraj; Mathew, Ian T et al. (2016) Impulsivity across the psychosis spectrum: Correlates of cortical volume, suicidal history, and social and global function. Schizophr Res 170:80-6
Padmanabhan, Jaya L; Nanda, Pranav; Tandon, Neeraj et al. (2016) Polygenic risk for type 2 diabetes mellitus among individuals with psychosis and their relatives. J Psychiatr Res 77:52-8
Hochberger, W C; Hill, S K; Nelson, C L M et al. (2016) Unitary construct of generalized cognitive ability underlying BACS performance across psychotic disorders and in their first-degree relatives. Schizophr Res 170:156-61
Francis, Alan N; Mothi, Suraj S; Mathew, Ian T et al. (2016) Callosal Abnormalities Across the Psychosis Dimension: Bipolar Schizophrenia Network on Intermediate Phenotypes. Biol Psychiatry 80:627-35
Hill, S Kristian; Reilly, James L; Ragozzino, Michael E et al. (2015) Regressing to Prior Response Preference After Set Switching Implicates Striatal Dysfunction Across Psychotic Disorders: Findings From the B-SNIP Study. Schizophr Bull 41:940-50
Kristian Hill, S; Buchholz, Alison; Amsbaugh, Hayley et al. (2015) Working memory impairment in probands with schizoaffective disorder and first degree relatives of schizophrenia probands extend beyond deficits predicted by generalized neuropsychological impairment. Schizophr Res 166:310-5
Mothi, Suraj Sarvode; Tandon, Neeraj; Padmanabhan, Jaya et al. (2015) Increased cardiometabolic dysfunction in first-degree relatives of patients with psychotic disorders. Schizophr Res 165:103-7
Lui, S; Yao, L; Xiao, Y et al. (2015) Resting-state brain function in schizophrenia and psychotic bipolar probands and their first-degree relatives. Psychol Med 45:97-108

Showing the most recent 10 out of 22 publications