The purpose of the proposed study is to use neuropsychological test and diffusion tensor imaging (DTI) to investigate the impact of white matter abnormalities on cognitive functioning among non-drug and alcohol abusing patients infected with Human Immunodeficiency Virus (HIV). Recent studies demonstrate the sensitivity of DTI in detecting white matter changes associated with HIV infection when compared to traditional structural MRI sequences. Preliminary data from our laboratory suggest that changes in the diffusion characteristics of HIV infected patients is also a better predictor of neuropsychological performance. The resent study will extend these preliminary data and examine in more detail the relationships between disease severity, neuropsychological testing and neuroimaging variables. To accomplish this, we will recruit two experimental HIV groups including 30 HIV infected non-drug/alcohol abusing patients with CD4 cell counts below 350 and 30 HIV infected non-drug/alcohol abusing patients with CD4 cell counts greater than350 and compare them to 20 demographically matched controls. Each participant will undergo neuropsychological testing and DTI neuroimaging. Differences between each of the groups will be investigated with the expectation that DTI variables will be more significantly altered in patients with thelowest CD4 cell counts. We also expect that the DTI variables for the control participants will be significantly different from the HIV patients with a higher CD4 cell count. We also expect that the DTI variables will be significantly predict changes in neurocognitive functioning among HIV infected patients and that DTI variables will be significantly related to disease severity. Though DTI has been used to investigate the neuropathological changes in HIV infected patients, this study will be one of the first to investigate these changes and their impact on cognitive functioning across multiple domains relative to measures of disease burden.

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Mentored Patient-Oriented Research Career Development Award (K23)
Project #
5K23MH073416-04
Application #
7268713
Study Section
Special Emphasis Panel (ZRG1-AARR-G (02))
Program Officer
Stoff, David M
Project Start
2005-08-24
Project End
2010-07-31
Budget Start
2007-09-02
Budget End
2008-07-31
Support Year
4
Fiscal Year
2007
Total Cost
$152,559
Indirect Cost
Name
Brigham and Women's Hospital
Department
Type
DUNS #
030811269
City
Boston
State
MA
Country
United States
Zip Code
02115
Ohtani, Toshiyuki; Nestor, Paul G; Bouix, Sylvain et al. (2017) Exploring the neural substrates of attentional control and human intelligence: Diffusion tensor imaging of prefrontal white matter tractography in healthy cognition. Neuroscience 341:52-60
Tate, David F; Khedraki, Rola; Neeley, E Shannon et al. (2011) Cerebral volume loss, cognitive deficit, and neuropsychological performance: comparative measures of brain atrophy: II. Traumatic brain injury. J Int Neuropsychol Soc 17:308-16
Tate, David F; Khedraki, Rola; McCaffrey, Daniel et al. (2011) The role of medical imaging in defining CNS abnormalities associated with HIV-infection and opportunistic infections. Neurotherapeutics 8:103-16
Tate, David F; Delong, Allison; McCaffrey, Daniel E et al. (2011) Recent clinical history and cognitive dysfunction for attention and executive function among human immunodeficiency virus-infected patients. Arch Clin Neuropsychol 26:614-23
Tate, D F; Neeley, E S; Norton, M C et al. (2011) Intracranial volume and dementia: some evidence in support of the cerebral reserve hypothesis. Brain Res 1385:151-62
Jefferson, Angela L; Holland, Christopher M; Tate, David F et al. (2011) Atlas-derived perfusion correlates of white matter hyperintensities in patients with reduced cardiac output. Neurobiol Aging 32:133-9
Tate, David F; Sampat, Mehul; Harezlak, Jaroslaw et al. (2011) Regional areas and widths of the midsagittal corpus callosum among HIV-infected patients on stable antiretroviral therapies. J Neurovirol 17:368-79
Kubicki, Marek; Alvarado, Jorge L; Westin, Carl-Fredrik et al. (2011) Stochastic tractography study of Inferior Frontal Gyrus anatomical connectivity in schizophrenia. Neuroimage 55:1657-64
Dewey, Jeffrey; Hana, George; Russell, Troy et al. (2010) Reliability and validity of MRI-based automated volumetry software relative to auto-assisted manual measurement of subcortical structures in HIV-infected patients from a multisite study. Neuroimage 51:1334-44
Cohen, Ronald A; Harezlak, Jaroslaw; Gongvatana, Assawin et al. (2010) Cerebral metabolite abnormalities in human immunodeficiency virus are associated with cortical and subcortical volumes. J Neurovirol 16:435-44

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