In this revised application for a Mentored Patient-Oriented Research Career Development Award (K23), Dr. David Kimhy will pursue training and research in the cognitive and neurobiological mechanisms of stress regulation and psychosis in schizophrenia. The goals of the training and research plan are integrated around the hypothesis that cognitive coping strategies mediate the link between stress and psychotic symptoms during recovery from psychosis in schizophrenia. Under the sponsorship of Dr. Dolores Malaspina, the training plan capitalizes on the resources of NYSPI/Columbia University, combining formal coursework, direct supervision, and clinical research experience and training. The plan involves mentorship and didactic instruction in key areas including: 1) psychosis research in schizophrenia using of Experience Sampling Method (ESM), 2) clinical methodologies for assessment of stress-regulating systems, 3) data analysis using multilevel linear modeling, and 4) cognitive-behavior therapy for psychosis (CBTp). Current methodologies have limited ecological validity to establish causal links between momentary changes in stress and psychosis. Dr. Kimhy will study simultaneously the real-time physiological and psychological correlates of psychosis using ambulatory assessment of cardiac autonomic regulation (Heart Rate Variability;HRV) synchronized with data collected using Experience Sampling Method (ESM) with Palm handheld computers. The research plan involves simultaneous probing of momentary psychotic symptoms, subjective stress, HRV, and cognitive coping strategies. Assessments will be conducted before and after pharmacological and CBTp treatments of psychosis. This methodology translates basic science into use in real-time, real-world environments (in-vivo and in-situ), allowing for the assessment of psychosis as part of the ebb-and-flow of daily functioning. Understanding these interactions will advance our understanding of the mechanisms of recovery from psychosis in schizophrenia. The proposed training and research plan will provide Dr. Kimhy with the knowledge, training, and experience necessary to develop as an independent researcher focusing on the neurobiological and psychological mechanisms of stress regulation and psychosis in schizophrenia.

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Mentored Patient-Oriented Research Career Development Award (K23)
Project #
5K23MH077653-04
Application #
7799744
Study Section
Adult Psychopathology and Disorders of Aging Study Section (APDA)
Program Officer
Chavez, Mark
Project Start
2007-05-17
Project End
2012-04-30
Budget Start
2010-05-01
Budget End
2011-04-30
Support Year
4
Fiscal Year
2010
Total Cost
$177,050
Indirect Cost
Name
Columbia University (N.Y.)
Department
Psychiatry
Type
Schools of Medicine
DUNS #
621889815
City
New York
State
NY
Country
United States
Zip Code
10032
Benavides, Caridad; Brucato, Gary; Kimhy, David (2018) Self-esteem and Symptoms in Individuals at Clinical High Risk for Psychosis. J Nerv Ment Dis 206:433-438
Kimhy, David; Wall, Melanie M; Hansen, Marie C et al. (2017) Autonomic Regulation and Auditory Hallucinations in Individuals With Schizophrenia: An Experience Sampling Study. Schizophr Bull 43:754-763
Kimhy, D; Gill, K E; Brucato, G et al. (2016) The impact of emotion awareness and regulation on social functioning in individuals at clinical high risk for psychosis. Psychol Med 46:2907-2918
Blum, Lisa H; Vakhrusheva, Julia; Saperstein, Alice et al. (2015) Depressed mood in individuals with schizophrenia: A comparison of retrospective and real-time measures. Psychiatry Res 227:318-23
Kimhy, David; Vakhrusheva, Julia; Liu, Ying et al. (2014) Use of mobile assessment technologies in inpatient psychiatric settings. Asian J Psychiatr 10:90-5
Kimhy, David; Vakhrusheva, Julia; Khan, Samira et al. (2014) Emotional granularity and social functioning in individuals with schizophrenia: an experience sampling study. J Psychiatr Res 53:141-8
Kimhy, David; Jobson-Ahmed, Lauren; Ben-David, Shelly et al. (2014) Cognitive insight in individuals at clinical high risk for psychosis. Early Interv Psychiatry 8:130-7
Kimhy, D; Tarrier, N; Essock, S et al. (2013) Cognitive Behavioral Therapy for Psychosis - Training Practices and Dissemination in the United States. Psychosis 5:
Kimhy, D; Crowley, O V; McKinley, P S et al. (2013) The association of cardiac vagal control and executive functioning--findings from the MIDUS study. J Psychiatr Res 47:628-35
Kimhy, David; Vakhrusheva, Julia; Jobson-Ahmed, Lauren et al. (2012) Emotion awareness and regulation in individuals with schizophrenia: Implications for social functioning. Psychiatry Res 200:193-201

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