(provided by candidate): This is a request for a Mentored Patient-Oriented Research Career Development Award (K23). The candidate is a clinical child and adolescent psychologist whose long-term goal is to develop family-focused interventions to optimize treatment outcomes for youth with pediatric OCD and related disorders. Her more immediate career objective is to launch an independent patient-oriented research career by gaining specific training in developing standardized family-based interventions;clinical intervention trial design and implementation;and quantitative methods for assessing developmental processes and mechanisms of change in clinical trials. To accomplish these goals, the candidate's career development plan will consist of select coursework and tutorials as well as mentorship in the following areas: (1) Treatment development for family-focused interventions;(2) Clinical intervention trial design and implementation;and (3) Quantitative methods for analyzing longitudinal intervention data. Training in these three areas will facilitate the following specific research aims: (1) To refine treatment concepts and develop a formal manual for the Positive Family Interaction Therapy (PFIT) program;(2) To conduct an open case series using the PFIT manual;(3) To implement a small controlled trial of the PFIT intervention;(4) To practice the timing and assessment of putative family factors that serve as mechanisms of change in the treatment of pediatric OCD.

Public Health Relevance

Pediatric OCD is a pervasive, chronic, and highly impairing illness. Although cognitive behavioral and pharmacological therapies have proven efficacious, a large proportion of youth fail to respond to these treatments. Given this, the development of evidence-based treatments tailored to the needs of treatment refractory cases is a clear public health priority.

National Institute of Health (NIH)
National Institute of Mental Health (NIMH)
Mentored Patient-Oriented Research Career Development Award (K23)
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Application #
Study Section
Interventions Committee for Disorders Involving Children and Their Families (ITVC)
Program Officer
Hill, Lauren D
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University of California Los Angeles
Schools of Medicine
Los Angeles
United States
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Wu, Monica S; Rozenman, Michelle; Peris, Tara S et al. (2018) Comparing OCD-affected youth with and without religious symptoms: Clinical profiles and treatment response. Compr Psychiatry 86:47-53
Peris, Tara S; Rozenman, Michelle; Bergman, R Lindsey et al. (2017) Developmental and clinical predictors of comorbidity for youth with obsessive compulsive disorder. J Psychiatr Res 93:72-78
Peris, Tara S; Rozenman, Michelle S; Sugar, Catherine A et al. (2017) Targeted Family Intervention for Complex Cases of Pediatric Obsessive-Compulsive Disorder: A Randomized Controlled Trial. J Am Acad Child Adolesc Psychiatry 56:1034-1042.e1
Rozenman, Michelle; Peris, Tara; Bergman, R Lindsey et al. (2017) Distinguishing Fear Versus Distress Symptomatology in Pediatric OCD. Child Psychiatry Hum Dev 48:63-72
Kircanski, Katharina; Peris, Tara S (2015) Exposure and response prevention process predicts treatment outcome in youth with OCD. J Abnorm Child Psychol 43:543-52
Peris, Tara S; Compton, Scott N; Kendall, Philip C et al. (2015) Trajectories of change in youth anxiety during cognitive-behavior therapy. J Consult Clin Psychol 83:239-52
De Nadai, Alessandro; Nagpal, Prianka S; Piacentini, John et al. (2015) Contemporary models of pediatric obsessive-compulsive disorder: An evaluation with a large clinical sample. Psychiatry Res 229:620-2
Galván, Adriana; Peris, Tara S (2014) Neural correlates of risky decision making in anxious youth and healthy controls. Depress Anxiety 31:591-8
Peris, Tara S; Piacentini, John (2013) Optimizing treatment for complex cases of childhood obsessive compulsive disorder: a preliminary trial. J Clin Child Adolesc Psychol 42:1-8
Peris, Tara S; Sugar, Catherine A; Bergman, R Lindsey et al. (2012) Family factors predict treatment outcome for pediatric obsessive-compulsive disorder. J Consult Clin Psychol 80:255-263

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