This integrated research and training plan will prepare Dr. Ranney, a fellowship-trained, practicing emergency physician, to become an independently funded physician-researcher with expertise in emergency department (ED)-based mental health interventions. Dr. Ranney's long-term research goal is to become an expert in developing effective, easily-disseminated, technology-augmented mental health interventions for high-risk ED patients. Her short-term goals, for this K23 Mentored Patient Oriented Career Development Award, are to (1) gain expertise in the development and evaluation of technology-augmented ED depression interventions, and (2) to test the hypothesis that a brief in-ED + longitudinal text-message (""""""""ED+text"""""""") indicated depression prevention intervention is acceptable and feasible for high-risk youth. Depressive symptoms and peer violence are common, significant, and strongly correlated causes of morbidity, mortality, and ED visits among adolescents. The ED is often the primary source of care for high-risk youth with depressive symptoms and history of peer violence. The ED is well established as a location for mental health intervention, yet few resources are available to high-risk youth. Most adolescent ED patients use text-messaging. Text-message behavioral change has been shown effective. In this project, Dr. Ranney and mentors will develop and pilot a single-session in-ED + 8 week longitudinal text-message program (""""""""ED+text"""""""") to reduce depressive symptoms, for adolescent ED patients with depressive symptoms and a history of peer violence. Under the guidance of a strong mentorship team of NIH-funded researchers, Dr. Ranney will achieve five specific training goals: (1) Gain advanced training in ED-based mental health research, focusing on the link between depression and violence;(2) Develop expertise in use of technology, particularly text-messaging, to enhance intervention delivery and evaluation;(3) Become a skilled user of qualitative research methodology to inform intervention development;(4) Learn how to design and conduct a clinical trial of an ED-based depression prevention intervention;(5) Develop skills in longitudinal data analysis for clinical trials. Dr. Ranney's training activities will be complemented by an innovative research plan allowing practical application of her new skills. Using a staged approach, Dr. Ranney will, first, conduct focus groups to develop our innovative """"""""ED+text"""""""" intervention content;next, refine the intervention through an iterative process of open trials;finally, test the acceptability and feasibility of the intervention through a randomized piot study (n=100). This work is a crucial step toward preventing depression and co-occurring disorders among a high-risk population that does not typically seek out services. It addresses a current lack of easily-accessible preventive interventions, addressing NIMH Strategic Objectives 3 (treatment development for diverse populations) and 4 (strengthening public health impact), as well as critical Adolescent and Mental Health objectives of Healthy People 2020.

Public Health Relevance

Depression and peer violence are significant, interrelated public health problems for adolescents. Although NIMH and Healthy People 2020 call for their prevention, this high-risk population is difficult to engage in traditional mental health care. Thi career development grant will allow Dr. Ranney to develop an innovative technology-augmented depression prevention intervention for high-risk adolescents seen in the emergency department.

National Institute of Health (NIH)
National Institute of Mental Health (NIMH)
Mentored Patient-Oriented Research Career Development Award (K23)
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Special Emphasis Panel (SERV)
Program Officer
Hill, Lauren D
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Rhode Island Hospital
United States
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Kimmel, Hannah J; Brice, Yanick N; Trikalinos, Thomas A et al. (2018) Real-Time Emergency Department Electronic Notifications Regarding High-Risk Patients: A Systematic Review. Telemed J E Health :
Ranney, Megan L; Bromberg, Julie; Hozey, Alyssa et al. (2018) Problem Behaviors and Psychological Distress Among Teens Seen in a National Sample of Emergency Departments. Acad Pediatr 18:650-654
Thorsen, Margaret M; Patena, John V; Guthrie, Kate Morrow et al. (2018) Using High-Risk Adolescents' Voices to Develop a Comprehensible Cognitive Behavioral Therapy-Based Text-Message Program. Behav Med 44:89-99
Ranney, Megan L; Goldstick, Jason; Eisman, Andria et al. (2017) Effects of a brief ED-based alcohol and violence intervention on depressive symptoms. Gen Hosp Psychiatry 46:44-48
Turcotte Benedict, Frances; Amanullah, Siraj; Linakis, James G et al. (2017) Emergency Department Utilization Among Assault-Injured Youth: Implications for Youth Violence Screening. Pediatr Emerg Care 33:607-612
Patton, Desmond U; Patel, Sadiq; Hong, Jun Sung et al. (2017) Tweets, Gangs, and Guns: A Snapshot of Gang Communications in Detroit. Violence Vict 32:919-934
Ranney, Megan L; Patena, John V; Nugent, Nicole et al. (2016) PTSD, cyberbullying and peer violence: prevalence and correlates among adolescent emergency department patients. Gen Hosp Psychiatry 39:32-8
Ranney, Megan L; Chang, Brian; Freeman, Joshua R et al. (2016) Tweet Now, See You In the ED Later? Examining the Association Between Alcohol-related Tweets and Emergency Care Visits. Acad Emerg Med 23:831-4
Resko, Stella M; Reddock, Ebony C; Ranney, Megan L et al. (2016) Reasons for Fighting among Violent Female Adolescents: A Qualitative Investigation from an Urban, Midwestern Community. Soc Work Public Health 31:99-112
Rising, Kristin L; Carr, Brendan G; Hess, Erik P et al. (2016) Patient-centered Outcomes Research in Emergency Care: Opportunities, Challenges, and Future Directions. Acad Emerg Med 23:497-502

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