This K23 application seeks support essential to my development as a patient oriented clinical investigator able to design, execute, and evaluate, theory-driven explanatory randomized clinical trials (RCTs). I am building a multi-method program of research to study how parents are drawn into accommodating their child's anxiety, and to intervene by modifying these patterns of enmeshment. I have conducted small clinical trials and have examined key biological and behavioral parent markers. I need to develop my skill and expertise in three core areas: 1) Designing and executing explanatory RCTs~ 2) Integrating bio-behavioral markers in explanatory RCTs~ 3) Applying statistical methods to test hypotheses of mediation and moderation in explanatory RCTs. To achieve these goals I have developed a training plan including regular meetings with all my sponsors, visits to other laboratories, courses seminars and workshops, independent reading, and scientific meetings. The superb and dedicated mentorship team ensures I receive strong, state of the art training. Their mentorship, the training activities, and the outstanding academic environment at the Yale Child Study Center, will provide me with the skills to launch an independent research career, starting with my first R01. The role of parents in the treatment of childhood anxiety remains unresolved. Including parents in the treatment process has not yielded superior effects compared to individual cognitive behavioral therapy (ICBT). One plausible conclusion from these data is that parent work cannot enhance effects treatment effects. This K23 focuses on an alternative plausible conclusion: That parent interventions need to be informed by theoretical working models of parent-specific mechanisms of change that are not targeted in ICBT~ and that parent interventions need to be evaluated in explanatory clinical trials asking not only 'doe treatment work?'but also 'how and for whom does treatment work?'Underlying systems that shape parents'responses to child anxiety provide clues to such parent-specific targets for intervention, and point to potential mediators and moderators of treatment response. Identifying mediators and moderators of response to parent interventions can enhance child anxiety outcomes and advance the goal of personalized psychotherapy. The SPACE Program (Supportive Parenting For Anxious Childhood Emotions) is a parent-based intervention that targets family accommodation (FA), of child anxiety. I propose an integrated explanatory clinical trial of SPACE, with ICBT as baseline comparison condition. The trial asks 3 main questions: 1) Will SPACE lead to significantly lower levels of FA compared to ICBT? 2) Will reducing FA lead to positive child outcomes? 3) Will key biological and behavioral markers (i.e., maternal oxytocin, autonomy granting, over involvement, sensitivity) moderate child outcomes? Children aged 7-14 (n=120), with primary anxiety disorders, will be randomized to either ICBT or SPACE. Results of this trial will guide the preparation of an R01 and have the potential to enhance treatment outcomes for the highly prevalent child anxiety disorders.
Childhood anxiety disorders are very common, carry tremendous personal and societal costs, frequently do not respond adequately to treatment, and involving parents in treatment has so far not enhanced outcomes. Explanatory clinical trials are needed to identify parent-specific mechanisms of change that are not targeted in direct child treatment, and to identify markers of who is most likely to benefit from parent intervention. This application proposes an explanatory clinical trial of a novel parent-based intervention and an investigation of biological and behavioral moderators of treatment response.
|Taylor, Jerome H; Lebowitz, Eli R; Jakubovski, Ewgeni et al. (2018) Monotherapy Insufficient in Severe Anxiety? Predictors and Moderators in the Child/Adolescent Anxiety Multimodal Study. J Clin Child Adolesc Psychol 47:266-281|
|Shimshoni, Yaara; Silverman, Wendy K; Byrne, Simon P et al. (2018) Maternal Acceptance Moderates Fear Ratings and Avoidance Behavior in Children. Child Psychiatry Hum Dev 49:460-467|
|Lebowitz, Eli R; François, Bernard (2018) Using Motion Tracking to Measure Avoidance in Children and Adults: Psychometric Properties, Associations With Clinical Characteristics, and Treatment-Related Change. Behav Ther 49:853-865|
|Schleider, Jessica L; Lebowitz, Eli R; Silverman, Wendy K (2018) Anxiety Sensitivity Moderates the Relation Between Family Accommodation and Anxiety Symptom Severity in Clinically Anxious Children. Child Psychiatry Hum Dev 49:187-196|
|Ventola, Pamela; Lei, Jiedi; Paisley, Courtney et al. (2017) Parenting a Child with ASD: Comparison of Parenting Style Between ASD, Anxiety, and Typical Development. J Autism Dev Disord 47:2873-2884|
|Lebowitz, Eli R (2017) Family Impairment Associated With Childhood Obsessive-Compulsive Disorder. J Am Acad Child Adolesc Psychiatry 56:187-188|
|Lebowitz, Eli R; Silverman, Wendy K; Martino, Alyssa M et al. (2017) Oxytocin response to youth-mother interactions in clinically anxious youth is associated with separation anxiety and dyadic behavior. Depress Anxiety 34:127-136|
|Omer, Haim; Lebowitz, Eli R (2016) Nonviolent Resistance: Helping Caregivers Reduce Problematic Behaviors in Children and Adolescents. J Marital Fam Ther 42:688-700|
|Silverman, Wendy K; Pettit, Jeremy W; Lebowitz, Eli R (2016) Stepping Toward Making Less More for Concerning Anxiety in Children and Adolescents. Clin Psychol (New York) 23:234-238|
|Forget, Hélène; Lacroix, André; Bourdeau, Isabelle et al. (2016) Long-term cognitive effects of glucocorticoid excess in Cushing's syndrome. Psychoneuroendocrinology 65:26-33|
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