This K23 application, in response to PA-11-194 to NINR, is a 3-year mentored patient-oriented research project to develop, adapt and test a self- and family-management intervention targeting HIV+ women in China to improve HIV health outcomes. The PI has extensive training experience at Columbia, University of California at San Francisco (UCSF), and the University of Washington (UW), and research experience in both domestic and international settings. Her long-term career goal is to be an independent and productive investigator in the field of HIV self- and family-management, with particular expertise in designing and implementing culturally sensitive interventions and to develop, test, implement, and evaluate an intervention in self- and family-management tailored to the Asian HIV+ population in the U.S. Training objectives for this award are to (a) gain expertise in qualitative data analysis for network text mining purposes as well as ethnographic evaluation;(b) learn gender, sexuality, and cultural adaptation skills to apply in a culturally sensitive study design;and (c) learn intervention development skills and apply them in developing a behavioral intervention for HIV+ women in China. The training activities designed to accomplish these objectives will include mentored independent study, formal course work, participation in research conferences, and design and implementation of a research project in Beijing to pilot test self- and family-intervention management among HIV+ women. This proposed research project is ambitious but feasible, as it will be coordinated with Dr. Simoni's ongoing work among HIV+ patients in Beijing and builds upon work that the PI has previously conducted with HIV+ women in Shanghai, China.
The specific aims of the research project are to: (a) conduct a secondary qualitative analysis of 68 in-depth interviews to further illuminate the sociocultural and family context of HIV+ Chinese women, (b) develop and adapt a theory-driven, culturally sensitive and feasible intervention to improve the quality of life and clinical outcomes of HIV+ Chinese women and their families, and (c) conduct a feasibility, compliance, and acceptability study for a self- and family-management intervention with 10 HIV+ women and their family members. The main goal is to adapt and develop an evidence-based culturally suitable self- and family-management intervention using Grey's self- and family-management framework. This intervention will assist HIV+ women in adjusting to their illness psychologically and socially, while helping them to decrease stress and enhance their level of social support. In the process, these women will also gain the knowledge and skills they need to cope with HIV. The applicant has chosen a seasoned mentor with extensive experience in the proposed research area, and has assembled a team of eminent academic collaborators across the U.S. and in China. Combining the skills and knowledge she has gained in her academic career thus far with the results of the proposed study, the applicant will be well positioned to submit applications as a principal investigator for further research on HIV in China.

Public Health Relevance

The proposed study will address a critical public health issue by helping HIV+ women throughout China. The study will develop a self- and family-management intervention for HIV+ women in China that will impact the women's disease experience both psychologically and socially. As a result of the intervention, these women will experience a decrease in stress and an increase in social support. At the same time, they will gain knowledge and skills needed to cope with HIV.

National Institute of Health (NIH)
National Institute of Nursing Research (NINR)
Mentored Patient-Oriented Research Career Development Award (K23)
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National Institute of Nursing Research Initial Review Group (NRRC)
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Hardy, Lynda R
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Yale University
Schools of Nursing
New Haven
United States
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Chen, Wei-Ti; Shiu, Chengshi; Yang, Joyce P et al. (2018) Quality of life in HIV-infected Chinese women and their family caregivers: an intervention study. AIDS Care 30:1572-1579
Chen, Wei-Ti; Barbour, Russell (2017) Life priorities in the HIV-positive Asians: a text-mining analysis in young vs. old generation. AIDS Care 29:507-510
Zhang, Lin; Chen, Wei-Ti; Yang, Joyce P et al. (2017) Disclosing Parental HIV Status to Children in China: Lessons Learned Through an Intervention Study. J Assoc Nurses AIDS Care 28:130-141
Wang, Kerong; Chen, Wei-Ti; Zhang, Lin et al. (2016) Facilitators of and barriers to HIV self-management: Perspectives of HIV-positive women in China. Appl Nurs Res 32:91-97
Yang, Joyce P; Xie, Tianyi; Simoni, Jane M et al. (2016) A Mixed-Methods Study Supporting a Model of Chinese Parental HIV Disclosure. AIDS Behav 20:165-73
Shi Shiu, Chen; Voisin, Dexter R; Chen, Wet-Ti et al. (2016) A Synthesis of 20 Years of Research on Sexual Risk Taking Among Asian/Pacific Islander Men Who Have Sex With Men in Western Countries. Am J Mens Health 10:170-80
Yu, Yu; Yang, Joyce P; Shiu, Cheng-Shi et al. (2015) Psychometric testing of the Chinese version of the Medical Outcomes Study Social Support Survey among people living with HIV/AIDS in China. Appl Nurs Res 28:328-33
Yu, Yu; Shiu, Cheng-Shi; Yang, Joyce P et al. (2015) Factor analyses of a social support scale using two methods. Qual Life Res 24:787-94
Chen, Wei-Ti; Guthrie, Barbara; Shiu, Cheng-Shi et al. (2015) Revising the American dream: how Asian immigrants adjust after an HIV diagnosis. J Adv Nurs 71:1914-25
Webel, Allison R; Wantland, Dean; Rose, Carol Dawson et al. (2015) A Cross-Sectional Relationship Between Social Capital, Self-Compassion, and Perceived HIV Symptoms. J Pain Symptom Manage 50:59-68

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