The primary objective of this Mentored Patient-Oriented Research Career-Development Award is to allow Meredith R. Golomb (the candidate) to develop the skills necessary to become an independent investigator in perinatal stroke research. Dr. Golomb has completed fellowships in child neurology and pediatric stroke, as well as a Masters of Science degree in Clinical Epidemiology. She wrote her MSc thesis on walking after perinatal stroke. She is an Assistant Professor at Indiana University (IU) School of Medicine, which, with its affiliated 4 hospitals, is the largest provider of tertiary pediatric care in Indiana. Dr. Golomb will take advanced classes in biostatistics, study design, and research ethics though IU's Clinical Investigator Training Program, which is funded though an NIH K30 grant, and work with investigators at the Regenstrief Institute for Health Care, which houses one of the oldest and most complete electronic medical records systems in the country. Dr. Golomb plans to describe the clinical characteristics and the motor, cognitive, and epilepsy outcomes in a retrospective cohort of all children with perinatal arterial ischemic stroke or sinovenous thrombosis seen at the IU-affiliated hospitals over the past 10 years, and to initiate a prospective cohort study documenting patient-oriented outcomes in more detail. She plans to use logistic regression modeling and Cox proportional hazards models to assess clinical characteristics as predictors of cognitive, motor, and epilepsy outcomes. The long-term goal of this study is to lay the foundation for future clinical trials of interventions designed to improve the outcomes of these children. During the last year of the study, she plans to apply for an R01 grant to set up a pilot clinical trial. ? ?

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Mentored Patient-Oriented Research Career Development Award (K23)
Project #
5K23NS048024-02
Application #
6884056
Study Section
NST-2 Subcommittee (NST)
Program Officer
Leblanc, Gabrielle G
Project Start
2004-06-01
Project End
2009-05-31
Budget Start
2005-06-01
Budget End
2006-05-31
Support Year
2
Fiscal Year
2005
Total Cost
$166,837
Indirect Cost
Name
Indiana University-Purdue University at Indianapolis
Department
Neurology
Type
Schools of Medicine
DUNS #
603007902
City
Indianapolis
State
IN
Country
United States
Zip Code
46202
Golomb, Meredith R; Warden, Stuart J; Fess, Elaine et al. (2011) Maintained hand function and forearm bone health 14 months after an in-home virtual-reality videogame hand telerehabilitation intervention in an adolescent with hemiplegic cerebral palsy. J Child Neurol 26:389-93
Burdea, Grigore C; Jain, Abhishek; Rabin, Bryan et al. (2011) Long-term hand tele-rehabilitation on the PlayStation 3: benefits and challenges. Conf Proc IEEE Eng Med Biol Soc 2011:1835-8
Barkat-Masih, Monica; Saha, Chandan; Golomb, Meredith R (2011) ASKing the kids: how children view their abilities after perinatal stroke. J Child Neurol 26:44-8
Brosch, Jared R; Sant, Roma V; Golomb, Meredith R (2011) Subacute onset of abnormal gait and head drop in a 3-year-old with history of extreme prematurity. J Child Neurol 26:373-6
Huber, Meghan; Rabin, Bryan; Docan, Ciprian et al. (2010) Feasibility of modified remotely monitored in-home gaming technology for improving hand function in adolescents with cerebral palsy. IEEE Trans Inf Technol Biomed 14:526-34
Barkat-Masih, Monica; Saha, Chandan; Hamby, Deborah K et al. (2010) Feeding problems in children with neonatal arterial ischemic stroke. J Child Neurol 25:867-72
Harris, Mandy O; Walsh, Laurence E; Hattab, Eyas M et al. (2010) Is it ADEM, POLG, or both? Arch Neurol 67:493-6
Golomb, Meredith R; Golomb, Herbert S (2010) What's eating you? Cat flea (Ctenocephalides felis). Cutis 85:10-1
Ting, Erica T; Golomb, Meredith R (2010) Grade IV fetal intracranial hemorrhage with good cognitive function. Pediatr Neurol 42:231-3
Golomb, Meredith R; Zimmer, Jennifer A; Garg, Bhuwan P (2010) Age-related variation in the presentation of childhood stroke varies with inclusion criteria. Acta Paediatr 99:6; author reply 7

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