This Career Development Award will support the growth of Dr. Daniel Licht into an independent clinical investigator with specialization in pediatric cerebrovascular injury. Dr. Licht's primary career development goal is to establish a multi-disciplinary research program encompassing the fields of neurology, critical care, and neuroimaging. To achieve these goals, Dr. Licht proposes collaborations between physicists and clinicians to develop new non-invasive methods for measuring cerebral blood flow (CBF) in newborn infants. Through modification and application of new imaging technologies, the proposed research will investigate the role of CBF in acquired brain injury in infants with severe congenital heart defects (CHD). CBF represents an important physiologic parameter for the understanding, diagnosis and management of neonatal brain disorders, and plays a pivotal role in brain injury in infants with severe CHD before heart surgery. In previous studies, Dr. Licht has found that deranged cerebrovascular physiology was associated with pre-operative structural brain injury. To further investigate this association, he proposes to measure and compare global and regional brain volumes in infants with CHD to those without CHD, and determine whether these differences are related to an altered CBF. Dr. Licht will use MRI based techniques to make these measurements and will test diffuse optic tomography (DOT) for comparative measurements. To date, both normative and disease data on pediatric brain perfusion remain sparse due to the lack of suitable techniques for CBF measurement. DOT is complimentary to MRI in that it offers excellent temporal resolution and can be applied at the point of care. Furthermore, DOT offers concurrent analysis of metabolic rate while sacrificing only mild anatomic resolution. ? ?

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Mentored Patient-Oriented Research Career Development Award (K23)
Project #
5K23NS052380-03
Application #
7252013
Study Section
NST-2 Subcommittee (NST)
Program Officer
Golanov, Eugene V
Project Start
2005-09-15
Project End
2010-06-30
Budget Start
2007-07-01
Budget End
2008-06-30
Support Year
3
Fiscal Year
2007
Total Cost
$133,272
Indirect Cost
Name
Children's Hospital of Philadelphia
Department
Type
DUNS #
073757627
City
Philadelphia
State
PA
Country
United States
Zip Code
19104
Jain, Varsha; Buckley, Erin M; Licht, Daniel J et al. (2014) Cerebral oxygen metabolism in neonates with congenital heart disease quantified by MRI and optics. J Cereb Blood Flow Metab 34:380-8
Goff, Donna A; Shera, David M; Tang, Stephen et al. (2014) Risk factors for preoperative periventricular leukomalacia in term neonates with hypoplastic left heart syndrome are patient related. J Thorac Cardiovasc Surg 147:1312-8
Dowling, Michael M; Hynan, Linda S; Lo, Warren et al. (2013) International Paediatric Stroke Study: stroke associated with cardiac disorders. Int J Stroke 8 Suppl A100:39-44
Buckley, Erin M; Lynch, Jennifer M; Goff, Donna A et al. (2013) Early postoperative changes in cerebral oxygen metabolism following neonatal cardiac surgery: effects of surgical duration. J Thorac Cardiovasc Surg 145:196-203, 205.e1; discussion 203
Buckley, Erin M; Naim, Maryam Y; Lynch, Jennifer M et al. (2013) Sodium bicarbonate causes dose-dependent increases in cerebral blood flow in infants and children with single-ventricle physiology. Pediatr Res 73:668-73
Kleinman, Jonathan T; Beslow, Lauren A; Engelmann, Kyle et al. (2012) Evaluation of intraventricular hemorrhage in pediatric intracerebral hemorrhage. J Child Neurol 27:526-31
Buckley, Erin M; Hance, Dalton; Pawlowski, Thomas et al. (2012) Validation of diffuse correlation spectroscopic measurement of cerebral blood flow using phase-encoded velocity mapping magnetic resonance imaging. J Biomed Opt 17:037007
Beslow, Lauren A; Kasner, Scott E; Smith, Sabrina E et al. (2012) Concurrent validity and reliability of retrospective scoring of the Pediatric National Institutes of Health Stroke Scale. Stroke 43:341-5
Ichord, Rebecca N; Bastian, Rachel; Abraham, Lisa et al. (2011) Interrater reliability of the Pediatric National Institutes of Health Stroke Scale (PedNIHSS) in a multicenter study. Stroke 42:613-7
Abend, Nicholas S; Beslow, Lauren A; Smith, Sabrina E et al. (2011) Seizures as a presenting symptom of acute arterial ischemic stroke in childhood. J Pediatr 159:479-83

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