This is an application for a K-23 Mentored Patient Oriented Career Development award entitled """"""""Time Course of Subthalamic Deep Brain Stimulation."""""""" The primary goal of the proposed research is to delineate new therapeutic mechanisms of action of Subthalamic nucleus deep brain stimulation (STN DBS). STN DBS is a highly effective, widely used treatment for Parkinson's disease (PD). Therapeutic effects of STN DBS persist for some time after stimulation ceases. Mechanisms of action of STN DBS, particularly of such """"""""persistent"""""""" effects, are not well understood. Experiments are proposed in which STN DBS effects on PD symptoms are measured over time when STN DBS is turned on and off in patients with STN stimulators implanted for treatment of PD, to test the hypothesis that the mechanism of lingering effects differs from that of """"""""immediate"""""""" effects seen during stimulation. Experiments are integrated with a computer simulation of neuronal biophysics to test the hypothesis that DBS-induced synaptic plasticity accounts for lingering effects. The candidate has clinical training in neurology/movement disorders, including PD and in DBS, including STN DBS for PD. He has research training in motor neurophysiology, in animal models. The goal of the proposed Career Development Award is to enable him to merge his clinical and research training in a program of patient oriented research focusing on the use of brain stimulation to study movement disorders and improve their treatment, using computer modeling techniques to relate cellular processes to clinical observable therapeutic effects. To this end, the candidate seeks training in 1) basal ganglia physiology and biophysics of DBS, 2) computer modeling techniques 3) patient oriented research.

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Mentored Patient-Oriented Research Career Development Award (K23)
Project #
5K23NS052523-05
Application #
8142844
Study Section
NST-2 Subcommittee (NST)
Program Officer
Sieber, Beth-Anne
Project Start
2007-09-01
Project End
2013-08-31
Budget Start
2011-09-01
Budget End
2013-08-31
Support Year
5
Fiscal Year
2011
Total Cost
$167,506
Indirect Cost
Name
Cleveland Clinic Lerner
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
135781701
City
Cleveland
State
OH
Country
United States
Zip Code
44195
Cooper, Scott E; Driesslein, Klaus G; Noecker, Angela M et al. (2014) Anatomical targets associated with abrupt versus gradual washout of subthalamic deep brain stimulation effects on bradykinesia. PLoS One 9:e99663
Cooper, Scott E; McIntyre, Cameron C; Fernandez, Hubert H et al. (2013) Association of deep brain stimulation washout effects with Parkinson disease duration. JAMA Neurol 70:95-9
Cooper, Scott Evan; Noecker, Angela Marie; Abboud, Hesham et al. (2011) Return of bradykinesia after subthalamic stimulation ceases: relationship to electrode location. Exp Neurol 231:207-13