Dr. M. Edip Gurol is a Stroke Neurologist and early-career investigator at Massachusetts General Hospital, whose goal is to become an independent investigator with expertise in molecular and functional imaging of small vessel brain diseases in the elderly. Dr. Gurol's career development plan leverages the resources of a world-class environment by bringing together an outstanding team of investigators from Massachusetts General Hospital and Harvard Medical School at the forefront of the field of small vessel brain disease (SVD). Dr. Gurol has already obtained strong preliminary results demonstrating the feasibility of a research plan that uses molecular and functional imaging to study mechanisms of tissue injury in cerebral amyloid angiopathy (CAA) and hypertensive arteriolosclerosis. Under the mentorship of Dr. Steven M. Greenberg, and co-Mentors Dr. Keith Johnson, Dr. Bruce Rosen and Dr. Rebecca Betensky, Dr. Gurol proposes: 1) to determine whether the severity of vascular amyloid deposition is associated with novel markers of hemorrhagic and ischemic tissue injury in CAA, 2) to map functional measures of vascular physiology and analyze its association of with amyloid deposits, ischemic brain lesions and cognitive deficits in SVD, and 3) to determine whether SVD- related microlesions (microbleeds and microinfarcts) are associated with in situ molecular changes and cognitive deficits. The overall goal of this proposal is to elucidate molecular mechanisms that result in hemorrhagic and ischemic brain injury in CAA and arteriolosclerosis, major causes of intracerebral hemorrhage and vascular cognitive impairment. Bringing together cutting-edge technology and a team with internationally recognized expertise, this project will both advance our understanding of a rapidly growing cause of disability in the elderly and serve as a strong training vehicle for Dr. Gurol's development as an independent investigator. Successful completion of the proposed studies, in concert with a structured didactic curriculum, will provide Dr. Gurol with the skills that are essential for him to develop an independent career in SVD research at the cutting edge of science. Using results on imaging markers of disease severity and progression obtained from the proposed projects, the candidate anticipates preparing his first independent RO1 application to identify innovative methods for prevention and treatment of SVD-related brain damage and cognitive impairment.

Public Health Relevance

Small vessel diseases of the brain are important causes of brain bleeds and cognitive impairment in our rapidly aging society. Dr. Gurol proposes a career development plan focused on advancing our knowledge of the molecular and physiological mechanisms of these small vessel diseases, a crucial step towards the discovery of effective treatment strategies.

National Institute of Health (NIH)
National Institute of Neurological Disorders and Stroke (NINDS)
Mentored Patient-Oriented Research Career Development Award (K23)
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Neurological Sciences Training Initial Review Group (NST)
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Corriveau, Roderick A
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Massachusetts General Hospital
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Pasi, Marco; Marini, Sandro; Morotti, Andrea et al. (2018) Cerebellar Hematoma Location: Implications for the Underlying Microangiopathy. Stroke 49:207-210
Tsai, Hsin-Hsi; Kim, Jong S; Jouvent, Eric et al. (2018) Updates on Prevention of Hemorrhagic and Lacunar Strokes. J Stroke 20:167-179
Gurol, M Edip (2018) Secondary Stroke Prevention in Atrial Fibrillation: New Insights Into an Old Problem. Stroke 49:1315-1317
Pasi, Marco; Charidimou, Andreas; Boulouis, Gregoire et al. (2018) Mixed-location cerebral hemorrhage/microbleeds: Underlying microangiopathy and recurrence risk. Neurology 90:e119-e126
Tsai, Hsin-Hsi; Pasi, Marco; Tsai, Li-Kai et al. (2018) Distribution of Lacunar Infarcts in Asians With Intracerebral Hemorrhage: A Magnetic Resonance Imaging and Amyloid Positron Emission Tomography Study. Stroke 49:1515-1517
Gurol, M Edip (2018) Nonpharmacological Management of Atrial Fibrillation in Patients at High Intracranial Hemorrhage Risk. Stroke 49:247-254
Tsivgoulis, Georgios; Katsanos, Aristeidis H; Schellinger, Peter D et al. (2018) Successful Reperfusion With Intravenous Thrombolysis Preceding Mechanical Thrombectomy in Large-Vessel Occlusions. Stroke 49:232-235
Murphy, Meredith P; Kuramatsu, Joji B; Leasure, Audrey et al. (2018) Cardioembolic Stroke Risk and Recovery After Anticoagulation-Related Intracerebral Hemorrhage. Stroke 49:2652-2658
Gokcal, Elif; Pasi, Marco; Fisher, Marc et al. (2018) Atrial Fibrillation for the Neurologist: Preventing both Ischemic and Hemorrhagic Strokes. Curr Neurol Neurosci Rep 18:6
Topcuoglu, Mehmet Akif; Liu, Liping; Kim, Dong-Eog et al. (2018) Updates on Prevention of Cardioembolic Strokes. J Stroke 20:180-196

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