This Mentored Patient-Oriented Research Career Development Award proposal contains didactic coursework, mentored instruction, and a clinical research project designed to apply the principles learned. The investigators' clinical research interest is in the integration of reproductive endocrinology with cognition, aging, and brain function and neurochemistry. The proposed clinical training and research studies in this application are designed to increase her skills in study design, biostatistics, cognitive neurosciences and neuroimaging techniques, with the ultimate goal of developing into an independent clinical investigator. The curriculum of the K30 Training Grant in Clinical Research, leading to a Master of Science in Clinical Research Design and Statistical Analysis at the UM, is included in the coursework. The goal of the research proposal is to study the neurobiological effects of long-term hormone therapy in healthy postmenopausal women. Sixty postmenopausal women, 60 years or older, will be recruited for this cross-sectional study (20 will never have used hormones, 20 will have used estrogen only for at least 10 years, and 20 will have used estrogen and progestin for at least 10 years). All women will undergo an extensive neuropsychological testing battery, a single photon emission computed tomography (SPECT) scan with a marker of cholinergic synaptic terminal density, an anatomic magnetic resonance image (MRI), and measures of estradiol and estrone. Ten women from each group will also undergo a functional MRI (fMRI) during a cognitive task designed to activate brain areas affected by estrogen and altered in Alzheimer's Disease. Comparison between groups will offer a greater understanding of the effect of hormone therapies on brain neurochemistry and cognition.

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
Mentored Patient-Oriented Research Career Development Award (K23)
Project #
5K23RR017043-03
Application #
6746015
Study Section
National Center for Research Resources Initial Review Group (RIRG)
Program Officer
Wilde, David B
Project Start
2002-06-15
Project End
2007-05-31
Budget Start
2004-06-01
Budget End
2005-05-31
Support Year
3
Fiscal Year
2004
Total Cost
$132,841
Indirect Cost
Name
University of Michigan Ann Arbor
Department
Obstetrics & Gynecology
Type
Schools of Medicine
DUNS #
073133571
City
Ann Arbor
State
MI
Country
United States
Zip Code
48109
Berent-Spillson, Alison; Kelley, Angela S; Persad, Carol C et al. (2018) Postmenopausal hormone treatment alters neural pathways but does not improve verbal cognitive function. Menopause 25:1424-1431
Shafir, Tal; Love, Tiffany; Berent-Spillson, Alison et al. (2012) Postmenopausal hormone use impact on emotion processing circuitry. Behav Brain Res 226:147-53
Smith, Yolanda R; Bowen, Luvina; Love, Tiffany M et al. (2011) Early initiation of hormone therapy in menopausal women is associated with increased hippocampal and posterior cingulate cholinergic activity. J Clin Endocrinol Metab 96:E1761-70
Berent-Spillson, Alison; Persad, Carol C; Love, Tiffany et al. (2010) Early menopausal hormone use influences brain regions used for visual working memory. Menopause 17:692-9
Love, Tiffany; Smith, Yolanda R; Persad, Carol C et al. (2010) Short-term hormone treatment modulates emotion response circuitry in postmenopausal women. Fertil Steril 93:1929-37
Persad, Carol C; Zubieta, Jon-Kar; Love, Tiffany et al. (2009) Enhanced neuroactivation during verbal memory processing in postmenopausal women receiving short-term hormone therapy. Fertil Steril 92:197-204
Reame, Nancy E; Lukacs, Jane L; Padmanabhan, Vasantha et al. (2008) Black cohosh has central opioid activity in postmenopausal women: evidence from naloxone blockade and positron emission tomography neuroimaging. Menopause 15:832-40
Smith, Yolanda R; Johnson, Angela M; Newman, Lisa A et al. (2007) Perceptions of clinical research participation among African American women. J Womens Health (Larchmt) 16:423-8
Rogers, Juliet L; Johnson, Timothy R B; Brown, Morton B et al. (2007) Recruitment of women research participants: the Women's Health Registry at the University of Michigan. J Womens Health (Larchmt) 16:721-8
Domino, Steven E; Smith, Yolanda R; Johnson, Timothy R B (2007) Opportunities and challenges of interdisciplinary research career development: implementation of a women's health research training program. J Womens Health (Larchmt) 16:256-61

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