This is an application for a K24 Midcareer Investigator Award in aging-related patient-oriented research. The candidate is a professor of psychiatry and epidemiology at the University of Pittsburgh with an established track record as a researcher, clinician, and educator. The proposed research is focused on Mild Cognitive Impairment (MCI), a variably defined condition generally regarded as a prodromal and/or risk state for AIzheimer's and other dementias. Its basic premise is that current """"""""diagnostic"""""""" criteria for MCI do not reflect the real-world distribution and outcomes in older adults in the typical community or clinical setting. In particular, MCI may be unstable and heterogeneous especially in patients with significant comorbidity and on multiple medications.
The aims of the Research Plan are to refine the criteria and propose new ones developed from: (1) analysis of existing data on MCI from a completed 15-year longitudinal community-based study of an aging cohort, and (2) an added focus on MCI in an ongoing study of older primary care patients. The refined criteria will be applied to (3) a new multicenter cohort study, for which methods and criteria will be derived from the preceding two components and pilot data will be collected during the K24. The Mentoring Plan is targeted towards beginning clinician investigators with excellent clinical and academic backgrounds and a commitment to clinical research in dementia and mild cognitive impairment. Trainees will obtain hands-on experience of patient-oriented research by conducting research assessments of patients participating in the ongoing primary care study (part 2 above), under supervision by the K24 awardee, and participating in the multidisciplinary consensus diagnosis conferences. They will also obtain supervised experience of analyzing, interpreting, and reporting data from the completed community study (part 1 above) for publication. A range of additional didactic and experiential programs is available depending on their interests and previous background. Each trainee will develop an independent research project application as part of the training and be evaluated on acquired knowledge, skills, and productivity.

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Midcareer Investigator Award in Patient-Oriented Research (K24)
Project #
5K24AG022035-05
Application #
7234334
Study Section
National Institute on Aging Initial Review Group (NIA)
Program Officer
Anderson, Dallas
Project Start
2003-06-01
Project End
2008-07-31
Budget Start
2007-06-01
Budget End
2008-07-31
Support Year
5
Fiscal Year
2007
Total Cost
$117,573
Indirect Cost
Name
University of Pittsburgh
Department
Psychiatry
Type
Schools of Medicine
DUNS #
004514360
City
Pittsburgh
State
PA
Country
United States
Zip Code
15213
Snitz, Beth E; Wang, Tianxiu; Cloonan, Yona Keich et al. (2018) Risk of progression from subjective cognitive decline to mild cognitive impairment: The role of study setting. Alzheimers Dement 14:734-742
Ganguli, Mary (2017) The times they are a-changin': cohort effects in aging, cognition, and dementia. Int Psychogeriatr 29:353-355
Graziane, Julie A; Beer, Joanne C; Snitz, Beth E et al. (2016) Dual Trajectories of Depression and Cognition: A Longitudinal Population-Based Study. Am J Geriatr Psychiatry 24:364-73
Ganguli, Mary; Fu, Bo; Snitz, Beth E et al. (2014) Vascular risk factors and cognitive decline in a population sample. Alzheimer Dis Assoc Disord 28:9-15
Andreescu, Carmen; Teverovsky, Esther; Fu, Bo et al. (2014) Old worries and new anxieties: behavioral symptoms and mild cognitive impairment in a population study. Am J Geriatr Psychiatry 22:274-84
Ganguli, Mary (2014) The unbearable lightness of MCI. Int Psychogeriatr 26:353-9
Metti, Andrea L; Yaffe, Kristine; Boudreau, Robert M et al. (2014) Change in inflammatory markers and cognitive status in the oldest-old women from the Study of Osteoporotic Fractures. J Am Geriatr Soc 62:662-6
Ganguli, Mary (2013) Can the DSM-5 framework enhance the diagnosis of MCI? Neurology 81:2045-50
Karp, Jordan F; Lee, Ching-Wen; McGovern, Jonathan et al. (2013) Clinical and demographic covariates of chronic opioid and non-opioid analgesic use in rural-dwelling older adults: the MoVIES project. Int Psychogeriatr 25:1801-10
Ganguli, Mary; Fu, Bo; Snitz, Beth E et al. (2013) Mild cognitive impairment: incidence and vascular risk factors in a population-based cohort. Neurology 80:2112-20

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