This is an application for a K24 mentoring award for patient-oriented research (POR) from Anne Cappola, MD, ScM, and Associate Professor of Medicine at the Perelman School of Medicine at the University of Pennsylvania (Penn). The candidate has a strong record of mentorship, leadership, and research productivity. Her research program encompasses translational and POR studies at the intersection of endocrinology and geriatrics. The scientific goal of this proposal is to investigate the physiologi underpinnings and clinical ramifications of subclinical hypothyroidism in the elderly. The candidate's NIA-funded R01 grant, plus two new aims examining the adaptability of the thyroid axis to aging, will form the basis for the training plan of the grant. Additional research opportunities are available in the candidate's other ongoing NIH-funded studies. The mentoring goals of this application are to engage and support the training of Penn fellows and junior faculty to conduct POR in aging. The career development goal of this application is to support the candidate's professional development and program building in clinical investigation. This will be achieved through engaging in sustained training experiences with two national experts, convening a local retreat on aging research, developing a training grant for POR in aging, and improving the national network of POR research in hormones and human aging. The institutional environment for clinical and translational science at Penn is outstanding, and the proposal integrates multiple programs from Penn's CTSA. The Department of Medicine at Penn has made a substantial commitment, including protected time and dedicated space, toward the candidate's sustained success as a patient-oriented researcher responsible for training a new generation of junior investigators who conduct research in older participants.

Public Health Relevance

Subclinical hypothyroidism, defined as high thyroid stimulating hormone levels with normal free thyroid hormone levels, is common in older people. However, it is not clear that treating older people with this condition benefits them. Dr. Cappola proposes to augment her scientific and mentoring skills, develop the local environment for mentoring new clinical investigators who perform patient-oriented research in older people, and conduct innovative studies to examine the adaptability of the thyroid axis to aging.

National Institute of Health (NIH)
National Institute on Aging (NIA)
Midcareer Investigator Award in Patient-Oriented Research (K24)
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Neuroscience of Aging Review Committee (NIA)
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Zieman, Susan
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University of Pennsylvania
Internal Medicine/Medicine
Schools of Medicine
United States
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Chaker, Layal; Baumgartner, Christine; den Elzen, Wendy P J et al. (2016) Thyroid Function Within the Reference Range and the Risk of Stroke: An Individual Participant Data Analysis. J Clin Endocrinol Metab 101:4270-4282
Chaker, Layal; Baumgartner, Christine; den Elzen, Wendy P J et al. (2015) Subclinical Hypothyroidism and the Risk of Stroke Events and Fatal Stroke: An Individual Participant Data Analysis. J Clin Endocrinol Metab 100:2181-91
Cappola, Anne R; Arnold, Alice M; Wulczyn, Kendra et al. (2015) Thyroid function in the euthyroid range and adverse outcomes in older adults. J Clin Endocrinol Metab 100:1088-96
Åsvold, Bjørn O; Vatten, Lars J; Bjøro, Trine et al. (2015) Thyroid function within the normal range and risk of coronary heart disease: an individual participant data analysis of 14 cohorts. JAMA Intern Med 175:1037-47