Sexually transmitted diseases exact a heavy toll on society. Annually, the number of STD cases exceed over 13 million in the United States and over 250 million cases worldwide. There is a current shortage of young clinical investigators, especially in areas with enormous public health import-such as STDs. Johns Hopkins has had a long tradition of performing clinical research in STDs and public health prevention, and provides a supportive setting for mentoring new investigators. This proposal will build on our past successful experiences in mentoring investigators. During the initial grant period, the PI established an STD Center for Excellence at Johns Hopkins, received a T32 training grant to fund trainees in STD research, received funding for 5 postdoctoral CDC STD fellows, mentored 32 pre and postdoctoral investigators resulting in 28 peer reviewed publications, instituted a seminar series and developed introductory and advanced courses in STD methods, including a course provided in distance education format. A unique aspect of the program is development of investigators at other institutions which do not have STD training capacity. In this renewal application, the PI proposes to continue developing mentoring relationships which will include: clinical experiences in the Baltimore STD clinics and Johns Hopkins AIDS Service; epidemiology and biostatistical training, and presentation and manuscript-writing skills. Mentees are supervised with weekly or biweekly conferences depending on skill level. Mentees at all levels are expected to develop an independent research project resulting in presentation at national meetings and publication.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Midcareer Investigator Award in Patient-Oriented Research (K24)
Project #
5K24AI001633-08
Application #
7210735
Study Section
Microbiology and Infectious Diseases B Subcommittee (MID)
Program Officer
David, Hagit S
Project Start
1999-04-01
Project End
2009-03-31
Budget Start
2007-04-01
Budget End
2009-03-31
Support Year
8
Fiscal Year
2007
Total Cost
$133,470
Indirect Cost
Name
Johns Hopkins University
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
001910777
City
Baltimore
State
MD
Country
United States
Zip Code
21218
Johnson, Hope L; Ghanem, Khalil G; Zenilman, Jonathan M et al. (2011) Sexually transmitted infections and adverse pregnancy outcomes among women attending inner city public sexually transmitted diseases clinics. Sex Transm Dis 38:167-71
Brotman, Rebecca M; Ravel, Jacques; Cone, Richard A et al. (2010) Rapid fluctuation of the vaginal microbiota measured by Gram stain analysis. Sex Transm Infect 86:297-302
Quan, Vu Minh; Go, Vivian F; Nam, Le Van et al. (2009) Risks for HIV, HBV, and HCV infections among male injection drug users in northern Vietnam: a case-control study. AIDS Care 21:7-16
Brotman, Rebecca M; Ghanem, Khalil G; Klebanoff, Mark A et al. (2008) The effect of vaginal douching cessation on bacterial vaginosis: a pilot study. Am J Obstet Gynecol 198:628.e1-7
Johnson, Hope L; Erbelding, Emily J; Zenilman, Jonathan M et al. (2007) Sexually transmitted diseases and risk behaviors among pregnant women attending inner city public sexually transmitted diseases clinics in Baltimore, MD, 1996-2002. Sex Transm Dis 34:991-4
Gesink Law, Dionne C; Bernstein, Kyle T; Serre, Marc L et al. (2006) Modeling a syphilis outbreak through space and time using the Bayesian maximum entropy approach. Ann Epidemiol 16:797-804
Bernstein, Kyle T; Zenilman, Jonathan; Olthoff, Glen et al. (2006) Gonorrhea reinfection among sexually transmitted disease clinic attendees in Baltimore, Maryland. Sex Transm Dis 33:80-6
Jadack, Rosemary A; Yuenger, Jeffrey; Ghanem, Khalil G et al. (2006) Polymerase chain reaction detection of Y-chromosome sequences in vaginal fluid of women accessing a sexually transmitted disease clinic. Sex Transm Dis 33:22-5
Reynolds, S J; Risbud, A R; Shepherd, M E et al. (2006) High rates of syphilis among STI patients are contributing to the spread of HIV-1 in India. Sex Transm Infect 82:121-6
Laffan, Alison M; Bellantoni, Michelle F; Greenough 3rd, William B et al. (2006) Burden of Clostridium difficile-associated diarrhea in a long-term care facility. J Am Geriatr Soc 54:1068-73

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