This is a competing renewal application for a K24 Mid-Career Award in Patient-Oriented Research for Richard E. Chaisson, MD, of the Johns Hopkins University School of Medicine. The applicant's original award proposed to provide support for patient oriented research on tuberculosis control in developing countries, mentoring of junior faculty and fellows in clinical research, and leadership of the Johns Hopkins Center for TB Research, which was founded at the time of the original award. All three aims have been executed with outstanding results. Dr. Chaisson's proposed community-randomized trial of alternative TB control strategies has been undertaken with support from a ICIDR program project grant and results will be available within a year. He has mentored a half-dozen junior faculty members and number of fellows, with notable success in terms of publications, funding and promotion. Finally, he has led the growth of the Center for TB Research from a $3 million enterprise to a world renowned center of excellence with more than $60 million in research funding. This recompetition application proposed to continue the leadership and management of the Center for TB Research, provide ongoing mentoring to five junior faculty and to fellows and graduate students, and to conduct innovative research on TB control strategies in developing countries by conducting a cluster-randomized, phase implementation study of INH preventive therapy for HIV-infected patients in Rio de Janeiro, Brazil. Support for these activities will enable Dr. Chaisson to further strengthen and expand the scope of the Center for TB Research, assist young investigators with academic advancement and success, and contribute to global tuberculosis control by developing new paradigms for reducing the burden of HIV-related TB.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Midcareer Investigator Award in Patient-Oriented Research (K24)
Project #
5K24AI001637-08
Application #
7214177
Study Section
Microbiology and Infectious Diseases B Subcommittee (MID)
Program Officer
Jacobs, Gail G
Project Start
1999-09-01
Project End
2010-03-31
Budget Start
2007-04-01
Budget End
2008-03-31
Support Year
8
Fiscal Year
2007
Total Cost
$155,375
Indirect Cost
Name
Johns Hopkins University
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
001910777
City
Baltimore
State
MD
Country
United States
Zip Code
21218
Golub, Jonathan E; Cohn, Silvia; Saraceni, Valeria et al. (2015) Long-term protection from isoniazid preventive therapy for tuberculosis in HIV-infected patients in a medium-burden tuberculosis setting: the TB/HIV in Rio (THRio) study. Clin Infect Dis 60:639-45
Dawson, R; Narunsky, K; Carman, D et al. (2015) Two-stage activity-safety study of daily rifapentine during intensive phase treatment of pulmonary tuberculosis. Int J Tuberc Lung Dis 19:780-6
Dowdy, David W; Golub, Jonathan E; Saraceni, Valeria et al. (2014) Impact of isoniazid preventive therapy for HIV-infected adults in Rio de Janeiro, Brazil: an epidemiological model. J Acquir Immune Defic Syndr 66:552-8
Azadi, M; Bishai, D M; Dowdy, D W et al. (2014) Cost-effectiveness of tuberculosis screening and isoniazid treatment in the TB/HIV in Rio (THRio) Study. Int J Tuberc Lung Dis 18:1443-8
Martinson, Neil A; Gupte, Nikhil; Msandiwa, Reginah et al. (2014) CD4 and viral load dynamics in antiretroviral-naïve HIV-infected adults from Soweto, South Africa: a prospective cohort. PLoS One 9:e96369
Saraceni, Valeria; Cohn, Silvia; Cavalcante, Solange C et al. (2014) Prevalent tuberculosis at HIV diagnosis in Rio de Janeiro, Brazil: the TB/HIV in Rio (THRio) Cohort. J Acquir Immune Defic Syndr 67:98-101
dos Santos, A P G; Pacheco, A G; Staviack, A et al. (2013) Safety and effectiveness of HAART in tuberculosis-HIV co-infected patients in Brazil. Int J Tuberc Lung Dis 17:192-7
Durovni, Betina; Saraceni, Valeria; Moulton, Lawrence H et al. (2013) Effect of improved tuberculosis screening and isoniazid preventive therapy on incidence of tuberculosis and death in patients with HIV in clinics in Rio de Janeiro, Brazil: a stepped wedge, cluster-randomised trial. Lancet Infect Dis 13:852-8
Lawn, S D; Harries, A D; Williams, B G et al. (2011) Antiretroviral therapy and the control of HIV-associated tuberculosis. Will ART do it? Int J Tuberc Lung Dis 15:571-81
Kakinami, Lisa; de Bruyn, Guy; Pronyk, Paul et al. (2011) The impact of highly active antiretroviral therapy on activities of daily living in HIV-infected adults in South Africa. AIDS Behav 15:823-31

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