application abstract): This K24 application requests funding for the candidate to pursue clinically oriented research at three sites: New England Medical Center in Boston; the University of Natal, Durban, South Africa; and the International Center for Diarrheal Disease Research in Dhaka, Bangladesh. The research studies focus on diarrheal diseases and the effects of antibiotic therapy, micronutrient supplementation, and HIV infection on the health of children and adults with diarrhea. Persons to be mentored by the Principal Investigator include junior faculty, fellows, medical students and graduate students from the New England Medical Center as well as trainees from the international centers at which the research will be conducted.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Midcareer Investigator Award in Patient-Oriented Research (K24)
Project #
5K24AI001671-04
Application #
6510036
Study Section
Microbiology and Infectious Diseases B Subcommittee (MID)
Program Officer
Sawyer, Leigh A
Project Start
1999-07-01
Project End
2004-06-30
Budget Start
2002-07-01
Budget End
2003-06-30
Support Year
4
Fiscal Year
2002
Total Cost
$107,924
Indirect Cost
Name
Tufts University
Department
Type
DUNS #
City
Boston
State
MA
Country
United States
Zip Code
02111
Chhagan, Meera K; Van den Broeck, Jan; Luabeya, Kany-Kany Angelique et al. (2014) Cost of childhood diarrhoea in rural South Africa: exploring cost-effectiveness of universal zinc supplementation. Public Health Nutr 17:2138-45
Khan, Wasif A; Griffiths, Jeffrey K; Bennish, Michael L (2013) Gastrointestinal and extra-intestinal manifestations of childhood shigellosis in a region where all four species of Shigella are endemic. PLoS One 8:e64097
Chhagan, Meera K; Van den Broeck, Jan; Luabeya, Kany-Kany A et al. (2010) Effect on longitudinal growth and anemia of zinc or multiple micronutrients added to vitamin A: a randomized controlled trial in children aged 6-24 months. BMC Public Health 10:145
Chhagan, M K; Van den Broeck, J; Luabeya, K-Ka et al. (2009) Effect of micronutrient supplementation on diarrhoeal disease among stunted children in rural South Africa. Eur J Clin Nutr 63:850-7
Mpontshane, Nontobeko; Van den Broeck, Jan; Chhagan, Meera et al. (2008) HIV infection is associated with decreased dietary diversity in South African children. J Nutr 138:1705-11
Zhang, Li; Radigan, Lin; Salzer, Ulrich et al. (2007) Transmembrane activator and calcium-modulating cyclophilin ligand interactor mutations in common variable immunodeficiency: clinical and immunologic outcomes in heterozygotes. J Allergy Clin Immunol 120:1178-85
Luabeya, Kany-Kany Angelique; Mpontshane, Nontobeko; Mackay, Malanie et al. (2007) Zinc or multiple micronutrient supplementation to reduce diarrhea and respiratory disease in South African children: a randomized controlled trial. PLoS One 2:e541
Rollins, N C; van den Broeck, J; Kindra, G et al. (2007) The effect of nutritional support on weight gain of HIV-infected children with prolonged diarrhoea. Acta Paediatr 96:62-8
Rollins, Nigel C; Coovadia, Hoosen M; Bland, Ruth M et al. (2007) Pregnancy outcomes in HIV-infected and uninfected women in rural and urban South Africa. J Acquir Immune Defic Syndr 44:321-8
Papathakis, Peggy C; Rollins, Nigel C; Chantry, Caroline J et al. (2007) Micronutrient status during lactation in HIV-infected and HIV-uninfected South African women during the first 6 mo after delivery. Am J Clin Nutr 85:182-92

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