application's abstract): John A. Bartlett seeks the K24 Mid-Career Investigator Award to enhance his opportunity to perform patient-oriented research, and mentor new investigators entering a career of clinical investigation. If Dr. Bartlett receives this award he will decrease his patient care responsibilities to 1/2 day per week, and he will receive biostatistical collaboration from Dr. Lloyd Edwards. Dr. Bartlett's research focuses on HIV pathogenesis and antiretroviral therapies, especially translational, investigator-initiated projects. His immediate research objectives include the investigation of antiretroviral treatment failure, and efforts to diminish the reservoir of chronically HIV-infected cells in persons receiving antiretroviral therapy. His long-term career objective centers on the continued incorporation of scientific observations on HIV pathogenesis into improved antiretroviral treatment strategies. Dr. Bartlett collaborates extensively with other basic and clinical sciences investigators at Duke University through ACTG, CFAR, SPIRAT and GCRC Awards, and his research efforts will be guided by a Scientific Advisory Committee. Dr. Bartlett has immediate access to 1058 HIV-infected adults and 109 HIV infected children followed at Duke University. He has successfully mentored numerous clinical investigators, including investigators involved with current projects. These mentorship activities are strongly supported by leadership of the Department of Medicine and the Division of Infectious Diseases, and an AIDS Training Grant, which provides financial support for young investigators.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Midcareer Investigator Award in Patient-Oriented Research (K24)
Project #
5K24AI001744-02
Application #
6372687
Study Section
Acquired Immunodeficiency Syndrome Research Review Committee (AIDS)
Program Officer
Batzold, Frederick
Project Start
2000-09-30
Project End
2005-05-31
Budget Start
2001-06-01
Budget End
2002-05-31
Support Year
2
Fiscal Year
2001
Total Cost
$85,985
Indirect Cost
Name
Duke University
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
071723621
City
Durham
State
NC
Country
United States
Zip Code
27705
Raymond, Kenneth N; Allred, Benjamin E; Sia, Allyson K (2015) Coordination Chemistry of Microbial Iron Transport. Acc Chem Res 48:2496-505
Tenorio, Allan R; Jiang, Hongyu; Zheng, Yu et al. (2009) Delaying a treatment switch in antiretroviral-treated HIV type 1-infected patients with detectable drug-resistant viremia does not have a profound effect on immune parameters: AIDS Clinical Trials Group Study A5115. AIDS Res Hum Retroviruses 25:135-9
Shorter, Meghan M; Ostermann, Jan; Crump, John A et al. (2009) Characteristics of HIV voluntary counseling and testing clients before and during care and treatment scale-up in Moshi, Tanzania. J Acquir Immune Defic Syndr 52:648-54
Morpeth, Susan C; Thielman, Nathan M; Ramadhani, Habib O et al. (2008) Effect of trimethoprim-sulfamethoxazole prophylaxis on antimicrobial resistance of fecal Escherichia coli in HIV-infected patients in Tanzania. J Acquir Immune Defic Syndr 47:585-91
Anderson, Albert M L; Kosinski, Andrzej S; Bartlett, John A (2007) Decreasing CD4+ T-cell count during suppressed or low-level viraemia in patients with HIV infection. Antivir Ther 12:1041-8
Riddler, Sharon A; Jiang, Hongyu; Tenorio, Allan et al. (2007) A randomized study of antiviral medication switch at lower- versus higher-switch thresholds: AIDS Clinical Trials Group Study A5115. Antivir Ther 12:531-41
Ramadhani, Habib O; Thielman, Nathan M; Landman, Keren Z et al. (2007) Predictors of incomplete adherence, virologic failure, and antiviral drug resistance among HIV-infected adults receiving antiretroviral therapy in Tanzania. Clin Infect Dis 45:1492-8
Bartlett, John A; Chen, Shan-Shan; Quinn, Joseph B (2007) Comparative efficacy of nucleoside/nucleotide reverse transcriptase inhibitors in combination with efavirenz: results of a systematic overview. HIV Clin Trials 8:221-6
Cai, Fangping; Chen, Haifeng; Hicks, Charles B et al. (2007) Detection of minor drug-resistant populations by parallel allele-specific sequencing. Nat Methods 4:123-5
Bartlett, John A; Buda, Jeffrey J; von Scheele, Birgitta et al. (2006) Minimizing resistance consequences after virologic failure on initial combination therapy: a systematic overview. J Acquir Immune Defic Syndr 41:323-31

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