This is a proposal for a continuation of the Midcareer Investigator Award in Patient-Oriented Research (K24) for Lee H. Harrison, MD, at the University of Pittsburgh. The principal aims of the award are to (1) continue to provide mentorship in patient-oriented research to junior faculty, graduate students, and infectious diseases fellows, (2) continue to provide leadership and direction to the Infectious Diseases Epidemiology Research Unit (IDERU) and Public Health Infectious Diseases Laboratory (PHIDL) at the University of Pittsburgh, and (3) support Dr. Harrison's research on the epidemiology and molecular epidemiology of serious bacterial pathogens. As with the first five years of the award, a major focus of the next five years will be to provide mentorship to infectious diseases fellows, graduate students, and junior faculty members. This will be accomplished by having dedicated time for mentorship and by making available substantial resources to trainees, including: the resources of the IDERU, which has a broad research portfolio of clinical, epidemiologic and molecular epidemiologic studies of bacterial diseases, and PHIDL, a cutting-edge molecular epidemiology laboratory, at the University of Pittsburgh;two NIH Fogarty International Center research training grants, one on the epidemiology and molecular epidemiology of serious bacterial diseases and another on HIV/AIDS;and the resources of the CDC-funded Maryland Active Bacterial Core Surveillance (ABCs) project, which is based at Johns Hopkins University and led by Dr. Harrison. One of the many studies that will be conducted during the award period includes a project entitled, """"""""Phase IV Study of Effectiveness Of Tetravalent (A, C, Y, W-135) Meningococcal Conjugate Vaccine """""""", a post-licensure study to measure the effectiveness of the new tetravalent meningococcal conjugate vaccine (MCV4). This will be a matched case-control effectiveness study which has the primary aim of determining overall effectiveness of MCV4 against vaccine preventable serogroups. Secondary aims of the study are to determine the serogroup-specific effectiveness of MCV4 against the two common vaccine preventable meningococcal serogroups in the United States, serogroups C and Y.

National Institute of Health (NIH)
National Institute of Allergy and Infectious Diseases (NIAID)
Midcareer Investigator Award in Patient-Oriented Research (K24)
Project #
Application #
Study Section
Microbiology and Infectious Diseases B Subcommittee (MID)
Program Officer
Taylor, Christopher E,
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
University of Pittsburgh
Internal Medicine/Medicine
Schools of Medicine
United States
Zip Code
Mustapha, Mustapha M; Marsh, Jane W; Krauland, Mary G et al. (2015) Genomic Epidemiology of Hypervirulent Serogroup W, ST-11 Neisseria meningitidis. EBioMedicine 2:1447-55
Galdys, Alison L; Nelson, Jemma S; Shutt, Kathleen A et al. (2014) Prevalence and duration of asymptomatic Clostridium difficile carriage among healthy subjects in Pittsburgh, Pennsylvania. J Clin Microbiol 52:2406-9
Curry, Scott R; Muto, Carlene A; Schlackman, Jessica L et al. (2013) Use of multilocus variable number of tandem repeats analysis genotyping to determine the role of asymptomatic carriers in Clostridium difficile transmission. Clin Infect Dis 57:1094-102
Higa, Fábio Takenori; Fukasawa, Lucila Okuyama; Gonçalves, Maria Gisele et al. (2013) Use of sodC versus ctrA for real-time polymerase chain reaction-based detection of Neisseria meningitidis in sterile body fluids. Mem Inst Oswaldo Cruz 108:246-7
Doi, Yohei; Kandiah, Sheena; Hariri, Rahman S et al. (2012) Natural history of multidrug-resistant Acinetobacter baumannii carriage in intensive care units. Infect Control Hosp Epidemiol 33:642-3
Gorla, Maria Cecília O; de Lemos, Ana Paula S; Quaresma, Márcia et al. (2012) Phenotypic and molecular characterization of serogroup C Neisseria meningitidis associated with an outbreak in Bahia, Brazil. Enferm Infecc Microbiol Clin 30:56-9
Park, Yoon Soo; Adams-Haduch, Jennifer M; Rivera, Jesabel I et al. (2012) Escherichia coli producing CMY-2 ?-lactamase in retail chicken, Pittsburgh, Pennsylvania, USA. Emerg Infect Dis 18:515-6
Curry, Scott R; Marsh, Jane W; Schlackman, Jessica L et al. (2012) Prevalence of Clostridium difficile in uncooked ground meat products from Pittsburgh, Pennsylvania. Appl Environ Microbiol 78:4183-6
Barroso, David E; Godoy, Daniel; Castiñeiras, Terezinha M P P et al. (2012) ?-Lactam resistance, serotype distribution, and genotypes of meningitis-causing Streptococcus pneumoniae, Rio de Janeiro, Brazil. Pediatr Infect Dis J 31:30-6
Curry, Scott R; Schlackman, Jessica L; Hamilton, Travis M et al. (2011) Perirectal swab surveillance for Clostridium difficile by use of selective broth preamplification and real-time PCR detection of tcdB. J Clin Microbiol 49:3788-93

Showing the most recent 10 out of 61 publications