The current proposal is a competitive renewal of a previously funded K24. The Principal Investigator, Dr. Anthony Harris, is an infectious disease physician and epidemiologist. During his fourteen years as faculty, he has had more than 125 manuscripts published. Among these manuscripts, he has been first or last author on more than 50. Most of these manuscripts have been focused in the following research areas: antimicrobial resistance, hospital epidemiology, infection control, and epidemiological and statistical methods in the study of antimicrobial resistance. His mentees have had over 450 publications from the time of his mentoring to the present. 101 publications have been mentee/mentor publications. Eighteen of 33 mentees are presently pursuing academic medical careers. In the initial five years of his K24, he successfully completed all proposed aims and mentored six faculty's career development awards. During the K24 period, he had over 46 publications of which 44 involved mentees. His current level of funding includes an NIH R01, an AHRQ R01, a CDC contract that has frequent requests for additional sub-contracts, a co-investigator on an NIH contract and two industry-sponsored research grants. Renewal of this K24 is critical to his desire to continue to mentor young investigators in the emerging areas of antibiotic-resistance, healthcare-associated infections and hospital epidemiology and to continue to evolve his research. He will take additional coursework to help move his research into the areas of cluster-randomized trials, genomic epidemiology, comparative effectiveness research and the study of the microbiome and antibiotic-resistance. The protected time is critical to Dr. Harris achieving these goals; without the K24 renewal, he will have to attend more on the infectious disease service and perform more hospital epidemiology and quality improvement in order to increase reimbursement directed towards his salary.

Public Health Relevance

Antibiotic-resistant bacteria and healthcare-associated infections increase patient morbidity and mortality; thus, they are an important public health concern. The proposed work will mentor young investigators in the emerging areas of antibiotic-resistance, healthcare-associated infections and hospital epidemiology and to continue to evolve research in these areas.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Midcareer Investigator Award in Patient-Oriented Research (K24)
Project #
5K24AI079040-10
Application #
9414576
Study Section
Microbiology and Infectious Diseases B Subcommittee (MID)
Program Officer
Ernst, Nancy L
Project Start
2009-02-23
Project End
2019-01-31
Budget Start
2018-02-01
Budget End
2019-01-31
Support Year
10
Fiscal Year
2018
Total Cost
Indirect Cost
Name
University of Maryland Baltimore
Department
Public Health & Prev Medicine
Type
Schools of Medicine
DUNS #
188435911
City
Baltimore
State
MD
Country
United States
Zip Code
21201
Alsaggaf, Rotana; O'Hara, Lyndsay M; Stafford, Kristen A et al. (2018) Quasi-experimental Studies in the Fields of Infection Control and Antibiotic Resistance, Ten Years Later: A Systematic Review. Infect Control Hosp Epidemiol 39:170-176
Harris, Anthony D; Sbarra, Alyssa N; Leekha, Surbhi et al. (2018) Electronically Available Comorbid Conditions for Risk Prediction of Healthcare-Associated Clostridium difficile Infection. Infect Control Hosp Epidemiol 39:297-301
Blanco, Natalia; Harris, Anthony D; Rock, Clare et al. (2018) Risk Factors and Outcomes Associated with Multidrug-Resistant Acinetobacter baumannii upon Intensive Care Unit Admission. Antimicrob Agents Chemother 62:
Sbarra, Alyssa N; Harris, Anthony D; Johnson, J Kristie et al. (2018) Guidance on Frequency and Location of Environmental Sampling for Acinetobacter baumannii. Infect Control Hosp Epidemiol 39:339-342
Evans, Scott R; Harris, Anthony D (2017) Methods and issues in studies of CRE. Virulence 8:453-459
Jackson, Sarah S; Leekha, Surbhi; Magder, Laurence S et al. (2017) Electronically Available Comorbidities Should Be Used in Surgical Site Infection Risk Adjustment. Clin Infect Dis 65:803-810
Johnson, J Kristie; Robinson, Gwen L; Pineles, Lisa L et al. (2017) Carbapenem MICs in Escherichia coli and Klebsiella Species Producing Extended-Spectrum ?-Lactamases in Critical Care Patients from 2001 to 2009. Antimicrob Agents Chemother 61:
O'Hara, Lyndsay M; Masnick, Max; Leekha, Surbhi et al. (2017) Indirect Versus Direct Standardization Methods for Reporting Healthcare-Associated Infections: An Analysis of Central Line-Associated Bloodstream Infections in Maryland. Infect Control Hosp Epidemiol 38:989-992
Jackson, Sarah S; Leekha, Surbhi; Magder, Laurence S et al. (2017) The Effect of Adding Comorbidities to Current Centers for Disease Control and Prevention Central-Line-Associated Bloodstream Infection Risk-Adjustment Methodology. Infect Control Hosp Epidemiol 38:1019-1024
Masnick, Max; Morgan, Daniel J; Sorkin, John D et al. (2017) Can National Healthcare-Associated Infections (HAIs) Data Differentiate Hospitals in the United States? Infect Control Hosp Epidemiol 38:1167-1171

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